Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 90399, Durham, NC, 27708, USA.
Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR, 97239, USA.
Support Care Cancer. 2019 Nov;27(11):4307-4316. doi: 10.1007/s00520-019-04710-7. Epub 2019 Mar 15.
Patients with metastatic breast cancer (MBC) experience high levels of symptoms. Yoga interventions have shown promise for improving cancer symptoms but have rarely been tested in patients with advanced disease. This study examined the acceptability of a comprehensive yoga program for MBC and the feasibility of conducting a randomized trial testing the intervention.
Sixty-three women with MBC were randomized with a 2:1 allocation to yoga or a support group comparison condition. Both interventions involved eight weekly group sessions. Feasibility was quantified using rates of accrual, attrition, and session attendance. Acceptability was assessed with a standardized self-report measure. Pain, fatigue, sleep quality, psychological distress, mindfulness, and functional capacity were assessed at baseline, post-intervention, and 3 and 6 months post-intervention.
We met goals for accrual and retention, with 50% of eligible patients enrolled and 87% of randomized participants completing post-intervention surveys. Sixty-five percent of women in the yoga condition and 90% in the support group attended ≥ 4 sessions. Eighty percent of participants in the yoga condition and 65% in the support group indicated that they were highly satisfied with the intervention. Following treatment, women in the yoga intervention had modest improvements in some outcomes; however, overall symptom levels were low for women in both conditions.
Findings suggest that the yoga intervention content was highly acceptable to patients with MBC, but that there are challenges to implementing an intervention involving eight group-based in-person sessions. Alternative modes of delivery may be necessary to reach patients most in need of intervention.
转移性乳腺癌（MBC）患者会经历较高水平的症状。瑜伽干预措施已显示出改善癌症症状的潜力，但在晚期疾病患者中很少进行测试。本研究考察了综合瑜伽方案在 MBC 中的可接受性，以及测试干预措施的随机试验的可行性。
63 名 MBC 患者按 2:1 的比例随机分为瑜伽组或支持组比较条件。两种干预措施均包括每周 8 次小组会议。通过入组率、失访率和课程出勤率来量化可行性。可接受性采用标准化自我报告措施进行评估。在基线、干预后以及干预后 3 个月和 6 个月评估疼痛、疲劳、睡眠质量、心理困扰、正念和功能能力。
我们达到了入组和保留的目标，有 50%的合格患者入组，87%的随机参与者完成了干预后调查。瑜伽组有 65%的女性和支持组有 90%的女性参加了≥4 次课程。瑜伽组有 80%的参与者和支持组有 65%的参与者表示非常满意干预措施。治疗后，瑜伽干预组的一些结果有适度改善；然而，两种情况下的女性症状总体水平都较低。
研究结果表明，瑜伽干预内容对 MBC 患者非常具有可接受性，但实施涉及 8 次基于小组的面对面课程的干预措施存在挑战。可能需要替代的交付模式才能接触到最需要干预的患者。
