Rosenthal A R, Egbert P R, Harbury C, Hopkins J L, Rubenstein E
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1978 Jul 17;207(2):111-5. doi: 10.1007/BF00414308.
A platelet-fibrinogen-thrombin mixture utilizing autologous platelets was studied for its potential to seal perforating corneal wounds. In rabbits, the mixture demonstrated sufficient adhesive properties to permit 75% of penetrating keratoplasties to remain in place without the use of sutures. All 12 grafts held initially; after 48 h three grafts extruded. In control eyes only two out of 12 (16%) of the corneal grafts remained in place. The material is simple to prepare and apply and is not toxic to the cornea. It does not cause inflammation or lid irritation. Intraocular complications observed with its use were transient anterior synechiae and retrocorneal membrane formation.
对一种利用自体血小板的血小板-纤维蛋白原-凝血酶混合物封闭角膜穿孔伤口的潜力进行了研究。在兔子身上，该混合物表现出足够的粘附特性，使得75%的穿透性角膜移植术在不使用缝线的情况下能够保持在位。所有12片移植片最初均固定在位；48小时后，3片移植片脱出。在对照眼中，12片角膜移植片中仅有2片（16%）保持在位。该材料制备和应用简单，对角膜无毒。它不会引起炎症或眼睑刺激。使用该材料时观察到的眼内并发症为短暂性前粘连和角膜后膜形成。
