Radiation Oncology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar-Verona, Italy.
Radiation Oncology, University Hospital, LMU Munich, Munich, Germany.
Crit Rev Oncol Hematol. 2019 Apr;136:13-19. doi: 10.1016/j.critrevonc.2019.02.002. Epub 2019 Feb 11.
Breast cancer, gynecological malignancies and lymphomas are the most frequently diagnosed tumors in pregnant women. The feasibility of radiotherapy during pregnancy remains a subject of debate and clinicians continue to hesitate on this approach, trying to avoid radiotherapy in most cases. Since the 1990s, several technological advances, including intensity modulated and image guided radiation delivery, have been implemented in radiation oncology to improve the radiation treatment in terms of effectiveness and tolerability. It remains uncertain which short- and long-term health effects the radiation exposure of the fetus may have through advanced radiotherapy techniques. The present systematic literature review aims to summarize the limited current evidences of the feasibility and clinical results of "modern" radiotherapy procedures for the treatment of the most frequently diagnosed tumors in pregnant women.
在孕妇中，乳腺癌、妇科恶性肿瘤和淋巴瘤是最常被诊断出的肿瘤。在怀孕期间进行放疗的可行性仍然存在争议，临床医生在这一方法上继续犹豫不决，试图在大多数情况下避免放疗。自 20 世纪 90 年代以来，放射肿瘤学领域实施了几项技术进步，包括强度调制和图像引导的放射治疗，以提高放射治疗的有效性和耐受性。目前还不确定通过先进的放射治疗技术，胎儿的辐射暴露可能会对其产生哪些短期和长期的健康影响。本系统文献综述旨在总结目前有限的证据，这些证据涉及“现代”放疗程序在治疗孕妇中最常见肿瘤的可行性和临床结果。
