Département de Gynécologie Obsétrique II et Médecine de la Reproduction, Faculté de Médecine, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Universitaire Paris Centre (HUPC), Centre Hospitalier Universitaire (CHU) Cochin, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Département "Développent, Reproduction et Cancer", INSERM U1016, Institut Cochin, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Département "Stress Oxydant, Prolifération Cellulaire et Inflammation", Institut Cochin, INSERM U1016, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Département de Gynécologie Obsétrique II et Médecine de la Reproduction, Faculté de Médecine, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Universitaire Paris Centre (HUPC), Centre Hospitalier Universitaire (CHU) Cochin, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Département "Développent, Reproduction et Cancer", INSERM U1016, Institut Cochin, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Département "Stress Oxydant, Prolifération Cellulaire et Inflammation", Institut Cochin, INSERM U1016, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Fertil Steril. 2019 May;111(5):944-952.e1. doi: 10.1016/j.fertnstert.2019.01.013. Epub 2019 Mar 14.
To examine whether serum antimüllerian hormone (AMH) levels correlate with the size of ovarian endometrioma (OMA).
An observational cross-sectional study.
University hospital.
PATIENT(S): Two hundred and sixty-seven nonpregnant women, aged 18-42 years, with no prior history of surgery for endometriosis and a histologically documented ovarian cyst.
INTERVENTION(S): Surgical management for a benign ovarian cyst.
MAIN OUTCOME MEASURE(S): Correlation between serum AMH concentration and cyst size according to OMA and non-OMA benign cyst.
RESULT(S): Women with OMA were compared with a control group of women who had non-OMA benign ovarian cysts. The AMH assay samples were collected less than a month before the surgery. Between January 2004 and September 2016, 148 women were allocated to the OMA group and 119 to the non-OMA benign cyst group. The AMH concentrations were not statistically significantly different between the two groups (3.7 ± 2.8 ng/mL vs. 4.1 ± 3.3 ng/mL). A multiple linear regression model accounting for potential confounders revealed that the log10 of the serum AMH concentration positively correlated with the log10 of the OMA cyst volume (R = 0.23; coefficient = 0.05; 95% CI, 0.007-0.10).
CONCLUSION(S): In women no prior history of surgery for endometriosis, serum AMH levels increased with cyst size in cases of OMA.
研究血清抗苗勒管激素（AMH）水平是否与卵巢子宫内膜瘤（OMA）的大小相关。
观察性横断面研究。
大学医院。
267 名年龄在 18-42 岁之间、无子宫内膜异位症手术史且经组织学证实为卵巢囊肿的非妊娠妇女。
良性卵巢囊肿的手术治疗。
根据 OMA 和非 OMA 良性囊肿，血清 AMH 浓度与囊肿大小的相关性。
将 OMA 患者与非 OMA 良性卵巢囊肿的对照组进行比较。AMH 检测样本在手术前不到一个月采集。2004 年 1 月至 2016 年 9 月期间，148 名妇女被分配到 OMA 组，119 名妇女被分配到非 OMA 良性囊肿组。两组间 AMH 浓度无统计学差异（3.7±2.8ng/mL 比 4.1±3.3ng/mL）。考虑到潜在混杂因素的多元线性回归模型显示，血清 AMH 浓度的对数与 OMA 囊肿体积的对数呈正相关（R=0.23；系数=0.05；95%CI，0.007-0.10）。
在无子宫内膜异位症手术史的妇女中，血清 AMH 水平在 OMA 病例中随囊肿大小的增加而升高。
