LANADA/Central Laboratory for Animal Diseases, BP 206 Bingerville, Ivory-Coast, Côte D'ivoire.
LANADA/Central Laboratory for Animal Diseases, BP 206 Bingerville, Ivory-Coast, Côte D'ivoire.
Res Vet Sci. 2019 Jun;124:118-122. doi: 10.1016/j.rvsc.2019.02.011. Epub 2019 Mar 1.
Peste des petits ruminants (PPR) is a major Transboundary animal disease (TADs) of sheep and goats in tropical regions caused by PPRV which can also infect cattle without any clinical signs but inducing seroconversion. However the epidemiological role of cattle in the maintenance and spread of the disease is not known. For the purposes of the present study, cattle were infected with a wild type candidate from each of the four lineages of PPRV and placed in separate boxes. Naive goats were then introduced into each specific box for the 30 days duration of the experiment. The results showed that no clinical signs of PPR were recorded in these infected cattle nor in the in-contact goats. The nasal and oral swabs remained negative. Serum from animals infected with three (3) of the wild type isolates of PPRV showed high percentage inhibition (PI % > 65%) in a cELISA. Only two animals out of three infected with the Nigeria 75/3 strain of lineage 2 (mild strain) had specific anti-PPR antibodies but with PI% values around the threshold of the test. Our findings suggest that cattle are dead-end hosts for PPRV and do not play an epidemiological role in the maintenance and spread of PPRV. In a PPR surveillance programme, cattle can serve as indicators of PPRV infection.
小反刍兽疫（PPR）是一种主要的跨界动物疾病（TADs），发生在热带地区的绵羊和山羊身上，由 PPRV 引起，也可以感染牛，但没有任何临床症状，只会诱导血清转化。然而，牛在疾病的维持和传播中的流行病学作用尚不清楚。在本研究中，牛感染了来自 PPRV 四个谱系的每种野生型候选物，并将它们放在单独的盒子里。然后，在实验的 30 天内，将未感染的山羊引入每个特定的盒子。结果表明，这些感染牛和接触的山羊均未出现 PPR 的临床症状。鼻拭子和口腔拭子均为阴性。在 cELISA 中，感染三种（3）种野生型 PPRV 分离株的动物血清显示出高百分比抑制（PI% > 65%）。只有感染 2 谱系尼日利亚 75/3 株（轻度株）的三只动物中的两只产生了特定的抗 PPR 抗体，但 PI% 值接近试验的阈值。我们的研究结果表明，牛是 PPRV 的死胡同宿主，在 PPRV 的维持和传播中不发挥流行病学作用。在 PPR 监测计划中，牛可以作为 PPRV 感染的指标。
