Dou Yongxi, Liang Zhongxiang, Prajapati Meera, Zhang Rui, Li Yanmin, Zhang Zhidong
State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Lanzhou, China.
CAAS-ILRI Joint Laboratory for Ruminant Disease Control, Lanzhou Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Lanzhou, China.
Front Vet Sci. 2020 Feb 28;7:66. doi: 10.3389/fvets.2020.00066. eCollection 2020.
Peste des petits ruminants (PPR) is a severe respiratory and digestive tract disease of domestic small ruminants caused by PPR virus (PPRV) of the genus . Although the primary hosts of PPRV are goats and sheep, the host range of PPRV has been continuously expanding and reported to infect various animal hosts over the last decades, which could bring a potential challenge to effectively control and eradicate PPR globally. In this review, we focused on current knowledge about host expansion and interspecies infection of PPRV and discussed the potential mechanisms involved.
小反刍兽疫（PPR）是由副黏病毒属的小反刍兽疫病毒（PPRV）引起的家养小反刍动物的一种严重呼吸道和消化道疾病。虽然PPRV的主要宿主是山羊和绵羊，但在过去几十年中，PPRV的宿主范围一直在不断扩大，并报道可感染各种动物宿主，这可能给在全球有效控制和根除PPR带来潜在挑战。在本综述中，我们重点关注了关于PPRV宿主扩展和种间感染的现有知识，并讨论了其中涉及的潜在机制。
