Norman D A, Fleischmann R M
Arthritis Rheum. 1978 Sep-Oct;21(7):811-9. doi: 10.1002/art.1780210712.
Mixed connective tissue disease is a clinical entity defined by overlapping features of progressive systemic sclerosis, systemic lupus erythematosus, polymyositis, rheumatoid arthritis, and distinct serologic findings. Esophageal dilatation and dysmotility have been the only gastrointestinal manifestations reported. Three patients with serologic findings of mixed connective tissue disease and extensive gastrointestinal involvement compatible with the changes found in progressive systemic sclerosis are presented. Gastrointestinal manifestations of progressive systemic sclerosis are reviewed and were found to be indistinguishable from the findings in these patients.
混合性结缔组织病是一种临床实体，由进行性系统性硬化症、系统性红斑狼疮、多发性肌炎、类风湿性关节炎的重叠特征以及独特的血清学表现所定义。食管扩张和运动障碍是唯一报道的胃肠道表现。本文介绍了3例具有混合性结缔组织病血清学表现且胃肠道广泛受累、与进行性系统性硬化症所见变化相符的患者。对进行性系统性硬化症的胃肠道表现进行了综述，发现与这些患者的表现难以区分。
