Integr Med (Encinitas). 2017 Aug;16(4):14-18.
The future for designing specific interventions targeting improvement in mitochondrial function employing personalized lifestyle intervention is bright given the significant progress that has been made in the field since early investigations in the mid-1980s. This progress is exemplified by the 2017 publication of a controlled exercise and diet intervention trial in obese adults that demonstrated significant improvement in energy, strength, peak oxygen consumption, quality of life, and bone mineral density after the tailored aerobic and resistance exercise program and calorie controlled diet. Being a part of this evolving field of mitochondrial function has been a wonderful experience-one that I have come to more fully appreciate as I look back with a historical perspective on my 30 years of involvement in personalized lifestyle medicine.
鉴于自20世纪80年代中期早期研究以来该领域已取得重大进展,采用个性化生活方式干预来设计针对改善线粒体功能的特定干预措施的前景十分光明。2017年发表的一项针对肥胖成年人的运动与饮食对照干预试验便是这一进展的例证,该试验表明,经过量身定制的有氧运动和抗阻运动计划以及热量控制饮食后,受试者在能量、力量、峰值耗氧量、生活质量和骨密度方面都有显著改善。作为线粒体功能这一不断发展领域的一部分,这是一段美妙的经历——当我从历史角度回顾自己参与个性化生活方式医学的30年时,我愈发充分地体会到了这一点。