文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

活性氧簇驱动辐射诱导纤维化中的表观遗传改变。

Reactive Oxygen Species Drive Epigenetic Changes in Radiation-Induced Fibrosis.

机构信息

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.

出版信息

Oxid Med Cell Longev. 2019 Feb 6;2019:4278658. doi: 10.1155/2019/4278658. eCollection 2019.

DOI:10.1155/2019/4278658
PMID:30881591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6381575/
Abstract

Radiation-induced fibrosis (RIF) develops months to years after initial radiation exposure. RIF occurs when normal fibroblasts differentiate into myofibroblasts and lay down aberrant amounts of extracellular matrix proteins. One of the main drivers for developing RIF is reactive oxygen species (ROS) generated immediately after radiation exposure. Generation of ROS is known to induce epigenetic changes and cause differentiation of fibroblasts to myofibroblasts. Several antioxidant compounds have been shown to prevent radiation-induced epigenetic changes and the development of RIF. Therefore, reviewing the ROS-linked epigenetic changes in irradiated fibroblast cells is essential to understand the development and prevention of RIF.

摘要

辐射诱导纤维化（RIF）在初次辐射暴露数月至数年后发展。当正常成纤维细胞分化为肌成纤维细胞并沉积异常数量的细胞外基质蛋白时，就会发生 RIF。导致 RIF 发展的主要因素之一是辐射暴露后立即产生的活性氧（ROS）。众所周知，ROS 的产生会诱导表观遗传变化，并导致成纤维细胞向肌成纤维细胞分化。已经有几种抗氧化化合物被证明可以预防辐射诱导的表观遗传变化和 RIF 的发展。因此，回顾辐照成纤维细胞中与 ROS 相关的表观遗传变化对于理解 RIF 的发展和预防至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3006/6381575/2d48d8d6567b/OMCL2019-4278658.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3006/6381575/cf6258c07c05/OMCL2019-4278658.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3006/6381575/2d48d8d6567b/OMCL2019-4278658.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3006/6381575/cf6258c07c05/OMCL2019-4278658.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3006/6381575/2d48d8d6567b/OMCL2019-4278658.002.jpg

相似文献

[1]
Reactive Oxygen Species Drive Epigenetic Changes in Radiation-Induced Fibrosis.

Oxid Med Cell Longev. 2019-2-6

[2]
Advances in pathogenic mechanisms and management of radiation-induced fibrosis.

Biomed Pharmacother. 2019-11-15

[3]
Radiation-induced gene expression in human subcutaneous fibroblasts is predictive of radiation-induced fibrosis.

Radiother Oncol. 2008-3

[4]
Epigenetic factors as drivers of fibrosis in systemic sclerosis.

Epigenomics. 2017-4

[5]
Stressing the (Epi)Genome: Dealing with Reactive Oxygen Species in Cancer.

Antioxid Redox Signal. 2017-9-25

[6]
More than a syllable in fib-ROS-is: The role of ROS on the fibrotic extracellular matrix and on cellular contacts.

Mol Aspects Med. 2018-4-6

[7]
Radiation-Induced Myofibroblasts Promote Tumor Growth via Mitochondrial ROS-Activated TGFβ Signaling.

Mol Cancer Res. 2018-7-24

[8]
Piperlongumine inhibits angiotensin II-induced extracellular matrix expression in cardiac fibroblasts.

J Cell Biochem. 2018-8-26

[9]
Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis.

Nat Commun. 2016-3-11

[10]
Protocatechuic acid attenuates angiotensin II-induced cardiac fibrosis in cardiac fibroblasts through inhibiting the NOX4/ROS/p38 signaling pathway.

Phytother Res. 2019-7-18

引用本文的文献

[1]
Redox Mechanisms Driving Skin Fibroblast-to-Myofibroblast Differentiation.

Antioxidants (Basel). 2025-4-18

[2]
Prevention and treatment of radiation injury by traditional Chinese medicine: A review.

Chin Herb Med. 2024-9-13

[3]
Understanding the early molecular changes associated with radiation therapy-A preliminary bulk RNA sequencing study.

PLoS One. 2025-3-3

[4]
The role of epithelial-mesenchymal transition in pulmonary fibrosis: lessons from idiopathic pulmonary fibrosis and COVID-19.

Cell Commun Signal. 2024-11-13

[5]
Obesity-induced fibrosis in osteoarthritis: Pathogenesis, consequences and novel therapeutic opportunities.

Osteoarthr Cartil Open. 2024-8-17

[6]
Hydrogen therapy promotes macrophage polarization to the M2 subtype in radiation lung injury by inhibiting the NF-κB signalling pathway.

Heliyon. 2024-5-11

[7]
[A transcriptomic analysis of correlation between mitochondrial function and energy metabolism remodeling in mice with myocardial fibrosis following myocardial infarction].

Nan Fang Yi Ke Da Xue Xue Bao. 2024-4-20

[8]
Tolerogenic dendritic cells in radiation-induced lung injury.

Front Immunol. 2023

[9]
The impact of physical activity on promoter-specific methylation of genes involved in the redox-status and disease progression: A longitudinal study on post-surgery female breast cancer patients undergoing medical treatment.

Redox Biol. 2024-4

[10]
SIRT1 as a potential key regulator for mediating apoptosis in oropharyngeal cancer using cyclophosphamide and all-trans retinoic acid.

Sci Rep. 2024-1-2

本文引用的文献

[1]
The Protective Effect of New Compound XH-103 on Radiation-Induced GI Syndrome.

Oxid Med Cell Longev. 2018-7-4

[2]
α7‑nAchR agonist GTS‑21 reduces radiation‑induced lung injury.

Oncol Rep. 2018-8-1

[3]
LSD1 mediated changes in the local redox environment during the DNA damage response.

PLoS One. 2018-8-10

[4]
Antifibrotic Agent Pirfenidone Protects against Development of Radiation-Induced Pulmonary Fibrosis in a Murine Model.

Radiat Res. 2018-7-17

[5]
Taurine provides a time-dependent amelioration of the brain damage induced by γ-irradiation in rats.

J Hazard Mater. 2018-7-9

[6]
A Metabolomic Serum Signature from Nonhuman Primates Treated with a Radiation Countermeasure, Gamma-tocotrienol, and Exposed to Ionizing Radiation.

Health Phys. 2018-7

[7]
CpG-oligodeoxynucleotides may be effective for preventing ionizing radiation induced pulmonary fibrosis.

Toxicol Lett. 2018-4-19

[8]
hTERT peptide fragment GV1001 demonstrates radioprotective and antifibrotic effects through suppression of TGF‑β signaling.

Int J Mol Med. 2018-3-14

[9]
Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP, Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation.

Antioxidants (Basel). 2018-3-7

[10]
Fractionated low-dose exposure to ionizing radiation leads to DNA damage, epigenetic dysregulation, and behavioral impairment.

Environ Epigenet. 2017-1-31

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索