Laakso S, Römer L, Mustakallio K K
Med Biol. 1986;64(1):43-5.
10-Butyryl substituted 1,8-dihydroxyanthrone (butantrone) inhibited soybean lipoxygenase-1 irreversibly and more efficiently than its parent compound 1,8-dihydroxyanthrone (dithranol, anthralin) (IC50 values 0.090 mM and 1.1 mM, respectively). Intact butantrone rather than its hydrolysis product was the primary effector and the 10-butyryl moiety its site specific probe, probably directing the inhibitor to the proximity of the binding site of the lipid substrate/product.
10-丁酰基取代的1,8-二羟基蒽醌（丁酮蒽酚）比其母体化合物1,8-二羟基蒽醌（地蒽酚，蒽林）更有效地不可逆抑制大豆脂氧合酶-1（IC50值分别为0.090 mM和1.1 mM）。完整的丁酮蒽酚而非其水解产物是主要效应物，10-丁酰基部分是其位点特异性探针，可能将抑制剂导向脂质底物/产物结合位点附近。
