Endo Hiroaki, Kase Satoru, Ito Yuki, Takahashi Mitsuo, Yokoi Masahiko, Katsuta Satoshi, Sonoda Shozo, Sakamoto Taiji, Ishida Susumu, Kase Manabu
Department of Ophthalmology, Teine Keijinkai Hospital, Sapporo, Japan.
Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15 W7, Kita-ku, Sapporo, 060-8638, Japan.
Graefes Arch Clin Exp Ophthalmol. 2019 Jun;257(6):1133-1140. doi: 10.1007/s00417-019-04295-1. Epub 2019 Mar 18.
The aim of this study was to evaluate the relationship between the choroidal structure of diabetic patients without diabetic retinopathy (DR) and duration of diabetes.
This study is a retrospective observational study in diabetic patients without DR. Eyes with diabetes mellitus (DM) (n = 105) were divided into two groups based on the duration: long duration group (over 10 years, n = 31) and short duration group (less than 10 years, n = 74). One hundred seventeen eyes of non-diabetic patients were used as control group. All patients underwent enhanced depth imaging optical coherence tomography, and the choroidal structure was analyzed using a binarization method.
There was no significant difference in areas of total choroid and lumina/stroma or central choroidal thickness (CCT) between control and DM groups. In contrast, lumina/total choroidal (L/C) ratio was significantly lower in diabetic eyes than in control eyes (P = 0.02). Although there was no significant difference in the areas or CCT between short and long duration groups, L/C ratio was significantly lower in the long duration group than in the short duration group (P = 0.03).
The current study suggests that choroidal vasculature is involved in the diabetic eyes and that the choroidal structure has changed with duration of diabetes. Our study points out that L/C ratio is a new potential biomarker in monitoring choroidal vascular disorders in diabetic eyes without DR.
本研究旨在评估无糖尿病视网膜病变（DR）的糖尿病患者脉络膜结构与糖尿病病程之间的关系。
本研究是一项针对无DR的糖尿病患者的回顾性观察研究。将糖尿病（DM）患者的眼睛（n = 105）根据病程分为两组：长病程组（超过10年，n = 31）和短病程组（少于10年，n = 74）。将117名非糖尿病患者的眼睛作为对照组。所有患者均接受增强深度成像光学相干断层扫描，并使用二值化方法分析脉络膜结构。
对照组和DM组之间在脉络膜总面积、管腔/基质面积或中心脉络膜厚度（CCT）方面无显著差异。相比之下，糖尿病患者眼睛的管腔/脉络膜总面积（L/C）比值显著低于对照组眼睛（P = 0.02）。虽然短病程组和长病程组在面积或CCT方面无显著差异，但长病程组的L/C比值显著低于短病程组（P = 0.03）。
当前研究表明脉络膜血管系统参与了糖尿病患者的眼睛病变，且脉络膜结构随糖尿病病程发生了变化。我们的研究指出，L/C比值是监测无DR的糖尿病患者眼睛脉络膜血管疾病的一种新的潜在生物标志物。
