Yao Huiping, Gao Sha, Liu Xiaoqing, Zhou Yufeng, Cheng Yu, Shen Xi
Department of Ophthalmology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Department of Ophthalmology, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai 201801, China.
J Ophthalmol. 2020 Oct 29;2020:5839837. doi: 10.1155/2020/5839837. eCollection 2020.
To determine the influence of phacoemulsification on choroidal vasculature in patients with diabetic retinopathy (DR) undergoing cataract surgery using swept-source optical coherence tomography (SS-OCT).
The study was conducted in 23 eyes of 23 cataract patients with mild/moderate nonproliferative diabetic retinopathy (NPDR) without diabetic macular edema (DME) and 23 age-matched controls. Choroidal thickness (CT) and choroidal vascularity index (CVI) were measured at baseline and 1 week, 1 month, and 3 months after surgery.
The baseline CVI in the DR group was significantly lower than that in the control group (=0.001). CVI in DR patients after surgery significantly increased compared with preoperative values (all < 0.001 for 1 week, 1 month, and 3 months after surgery). Postoperative increase of CVI and CT in the DR group was more than in the control group, and the difference was significant 1 month and 3 months after surgery (all < 0.05).
Patients with mild/moderate NPDR have reduced CVI compared with nondiabetic patients at baseline; diabetic cataract surgery tended to induce more increase in CVI and CT as compared with nondiabetic patients. This trial is registered with NCT04499768.
使用扫频光学相干断层扫描（SS-OCT）确定白内障手术对糖尿病视网膜病变（DR）患者脉络膜血管系统的影响。
对23例患有轻度/中度非增殖性糖尿病视网膜病变（NPDR）且无糖尿病性黄斑水肿（DME）的白内障患者的23只眼以及23例年龄匹配的对照者进行了研究。在基线以及术后1周、1个月和3个月测量脉络膜厚度（CT）和脉络膜血管指数（CVI）。
DR组的基线CVI显著低于对照组（=0.001）。DR患者术后的CVI与术前值相比显著增加（术后1周、1个月和3个月时均<0.001）。DR组术后CVI和CT的增加幅度大于对照组，且在术后1个月和3个月时差异显著（均<0.05）。
轻度/中度NPDR患者在基线时的CVI低于非糖尿病患者；与非糖尿病患者相比，糖尿病白内障手术往往会使CVI和CT增加更多。本试验已在NCT04499768注册。
