Tsiogka Anastasia, Petrou Petros, Droutsas Konstantinos, Nikolopoulou Anthi, Papaconstantinou Dimitrios, Chatzistefanou Klio I
Ophthalmology, 401 General Military Hospital of Athens, Athens, GRC.
Ophthalmology, General Hospital of Athens "G. Gennimatas", Athens, GRC.
Cureus. 2023 Feb 15;15(2):e35027. doi: 10.7759/cureus.35027. eCollection 2023 Feb.
To investigate correlations of exophthalmometry values (EVs) with age, gender, and the presence of diabetes mellitus, arterial hypertension, and dyslipidemia.
In a cross-sectional, clinic-based study, consecutive adult Greek patients presenting for evaluation at the outpatient general clinic on a scheduled appointment basis at a tertiary care referral center were submitted to Hertel exophthalmometry in both eyes by the same observer. Subjects with signs of history or orbital pathology, including thyroid-associated ophthalmopathy, were excluded. Demographics, as well as a detailed systemic history report, were recorded. Mixed effect linear regression analysis was performed to account for the correlation between the eyes of the same participant.
A total of 800 eyes (400 subjects) were included, 194 males and 206 females, with a mean age of 67.82 ± 12 years (range: 18-92 years). The mean exophthalmometry value was 15.7 ± 2.6 mm (range: 11-21 mm). Every one year of increase in age is associated with a decrease in EVs by 0.03 mm (95% CI -0.04, -0.02/p-value<0.001). Female gender was associated with lower EVs by 0.33mm (95% CI-0.56, -0.1/p-value=0.005). Patients with diabetes mellitus had higher EVs by 0.47 mm (95% CI 0.25, 0.70/p-value<0.001) compared to patients without diabetes, and patients with arterial hypertension had lower EVs by 0.26 mm (95% CI -0.5, -0.02/p-value=0.034) compared to patients without hypertension. No association was found between dyslipidemia and systemic history of thyroid dysfunction. Conclusions: A negative correlation of EVs was noted with increasing age, female gender, as well as history of arterial hypertension and a positive correlation with diabetes mellitus.
研究眼球突出度值（EVs）与年龄、性别、糖尿病、动脉高血压和血脂异常之间的相关性。
在一项基于门诊的横断面研究中，在一家三级医疗转诊中心按预约在门诊普通诊所就诊的连续成年希腊患者由同一名观察者对双眼进行Hertel眼球突出度测量。排除有病史或眼眶病变体征的受试者，包括甲状腺相关性眼病。记录人口统计学资料以及详细的全身病史报告。进行混合效应线性回归分析以考虑同一参与者双眼之间的相关性。
共纳入800只眼（400名受试者），其中男性194名，女性206名，平均年龄67.82±12岁（范围：18 - 92岁）。平均眼球突出度值为15.7±2.6mm（范围：11 - 21mm）。年龄每增加一岁，EVs降低0.03mm（95%CI -0.04，-0.02/p值<0.001）。女性性别与EVs降低0.33mm相关（95%CI -0.56，-0.1/p值=0.005）。与无糖尿病患者相比，糖尿病患者的EVs高0.47mm（95%CI 0.25，0.70/p值<0.001），与无高血压患者相比，动脉高血压患者的EVs低0.26mm（95%CI -0.5，-0.02/p值=0.034）。未发现血脂异常与甲状腺功能障碍的全身病史之间存在关联。结论：EVs与年龄增加、女性性别以及动脉高血压病史呈负相关，与糖尿病呈正相关。
