Matsui K, Mano Y, Ando K
Yakubutsu Seishin Kodo. 1986 Jun;6(2):281-3.
The behavioral effects of thyrotropin-releasing hormone (TRH) and a TRH analogue, DN-1417 (butyrolactone-carbonyl-L-histidyl-L-prolinamide citrate) on the ataxia of Rolling mouse Nagoya and Staggerer mouse were examined using open-field methods. The ataxic gaits improved after injection of TRH (25 mg/kg, ip) and DN-1417 (5.25 mg/kg ip), compared with injection of saline. As a whole, the improving effect of DN-1417 persisted about 2 or more times as long in duration as that of TRH.
使用旷场法研究了促甲状腺激素释放激素（TRH）及其类似物DN-1417（丁内酯-羰基-L-组氨酰-L-脯氨酰胺柠檬酸盐）对滚动小鼠名古屋品系和蹒跚小鼠共济失调的行为影响。与注射生理盐水相比，注射TRH（25mg/kg，腹腔注射）和DN-1417（5.25mg/kg，腹腔注射）后，共济失调步态得到改善。总体而言，DN-1417的改善效果持续时间约为TRH的2倍或更长。
