Matsui K, Ando K
Jikken Dobutsu. 1984 Oct;33(4):465-9. doi: 10.1538/expanim1978.33.4_465.
Antiataxic mechanisms were investigated in Rolling mouse Nagoya (RMN). The present study was to elucidate the influence of dopaminergic (pimozide, apomorphine) and cholinergic (atropine, physostigmine) drugs on the antiataxic effect of TRH. The degree of ataxic gait and spontaneous motor activities in RMN were measured by the open field method and ANIMEX-II Pretreatment with pimozide and apomorphine had no influence on the antiataxic effects of TRH, while pretreatment with physostigmine suppressed these effects and in contrast, with atropine, increased then. The increase of spontaneous motor activities after TRH injection was antagonized by pretreatment with pimozide and physostigmine, but accentuated by pretreatment with atropine. These results may indicate that the antiataxic effects of TRH are, at least partially, mediated by the cholinergic mechanism.
在滚动小鼠名古屋（RMN）中研究了抗共济失调机制。本研究旨在阐明多巴胺能药物（匹莫齐特、阿扑吗啡）和胆碱能药物（阿托品、毒扁豆碱）对促甲状腺激素释放激素（TRH）抗共济失调作用的影响。通过旷场法和ANIMEX-II测量RMN中共济失调步态的程度和自发运动活动。匹莫齐特和阿扑吗啡预处理对TRH的抗共济失调作用没有影响，而毒扁豆碱预处理会抑制这些作用，相反，阿托品预处理则会增强这些作用。TRH注射后自发运动活动的增加被匹莫齐特和毒扁豆碱预处理所拮抗，但被阿托品预处理所增强。这些结果可能表明，TRH的抗共济失调作用至少部分是由胆碱能机制介导的。
