Doheny Image Reading Center, Doheny Eye Institute.
Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA.
J Glaucoma. 2019 Jun;28(6):557-562. doi: 10.1097/IJG.0000000000001242.
PRéCIS:: By using OCT-A, we observed a reduction of the superficial macular, peripapillary, and optic nerve, as well as the choriocapillaris in eyes with low tension glaucoma, compared with normal controls.
The purpose of this study was to investigate macular and optic disc vascular parameters in patients with low tension glaucoma (LTG) using optical coherence tomography angiography (OCTA).
In this cross-sectional study, images were prospectively acquired from both eyes of 26 patients with clinically diagnosed LTG and 22 age-matched volunteers with normal healthy eyes using the Zeiss swept-source (SS) OCTA (Plex Elite 9000, Carl Zeiss Meditec). Perfusion density (PD) and vessel length density (VLD) within a 5 mm diameter circle centered over the macula and optic nerve head were analyzed.
The final analysis cohort included 49 eyes with LTG and 40 healthy control eyes. Mean age was 60±10 years in the LTG group and 60±17 years in the control group. The LTG group had a statistically significant reduction in PD of the choriocapillaris (CC) compared with normal controls (71.74±8.37% vs. 80.48±3.84%; P<0.001). There was no statistically significant difference in PD between the LTG and control groups for the superficial vascular plexus (SVP), deep capillary plexus (DCP) or the optic nerve head and peripapillary area (ONH+PP) (P>0.05). The LTG group did show statistically significant reductions in VLD compared with normal controls for the SVP (2083.64±153.76 mm/mm vs. 2154.63±144.18 mm/mm; P=0.03) and ONH + PP (1813.76±271.69 mm/mm vs. 1950.23±169.33 mm/mm; P=0.03), whereas the DCP VD was similar between the 2 groups (P>0.05).
Eyes with low tension glaucoma seems to show a lower CC perfusion density, as well as a lower SVP and ONH+PP vessel length density compared to normal eyes.
摘要：通过 OCT-A，我们观察到与正常对照组相比，低眼压性青光眼患者的浅层黄斑、视盘周围和视神经以及脉络膜毛细血管均减少。目的：本研究旨在通过光相干断层扫描血管造影术（OCTA）研究低眼压性青光眼（LTG）患者的黄斑和视盘血管参数。方法：在这项横断面研究中，使用 Zeiss 扫频源（SS）OCTA（Plex Elite 9000，卡尔蔡司医疗技术公司）对 26 例临床诊断为 LTG 的患者和 22 例年龄匹配的健康正常眼的双眼进行前瞻性图像采集。分析以黄斑和视神经头为中心的 5mm 直径圆内的灌注密度（PD）和血管长度密度（VLD）。结果：最终分析队列包括 49 只 LTG 眼和 40 只健康对照眼。LTG 组的平均年龄为 60±10 岁，对照组为 60±17 岁。与正常对照组相比，LTG 组脉络膜毛细血管（CC）的 PD 显著降低（71.74±8.37%对 80.48±3.84%；P<0.001）。LTG 组与对照组之间浅层血管丛（SVP）、深层毛细血管丛（DCP）或视神经头和视盘周围区域（ONH+PP）的 PD 无统计学差异（P>0.05）。与正常对照组相比，LTG 组的 SVP（2083.64±153.76mm/mm 对 2154.63±144.18mm/mm；P=0.03）和 ONH+PP（1813.76±271.69mm/mm 对 1950.23±169.33mm/mm；P=0.03）的 VLD 明显降低，而两组之间 DCP 的 VLD 相似（P>0.05）。结论：与正常眼相比，低眼压性青光眼患者的 CC 灌注密度较低，SVP 和 ONH+PP 血管长度密度也较低。
