一种简便的水热合成法制备高发光的 NaYF:Yb/Er 上转换纳米粒子及其生物监测性能。

A facile hydrothermal synthesis of highly luminescent NaYF:Yb/Er upconversion nanoparticles and their biomonitoring capability.

机构信息

Department of Chemistry, Institute of Interdisciplinary Convergence Research, Research Institute of Halal Industrialization Technology, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea.

出版信息

Mater Sci Eng C Mater Biol Appl. 2019 Jun;99:1067-1074. doi: 10.1016/j.msec.2019.02.046. Epub 2019 Feb 15.

DOI:10.1016/j.msec.2019.02.046

PMID:30889639

Abstract

Using a facile hydrothermal procedure, hydrophilic NaYF: Yb/Er nanoparticles (NPs) have been prepared as lanthanide-doped upconversion (UC) materials exhibiting different morphologies, crystal phases and luminescence intensity. The upconversion nanoparticles (UCNP) were characterized by means of electron microscopy and spectroscopy, X-ray diffraction (XRD) and photoluminescence analysis. The molar concentration of reactants and volumes of NaF affect the shapes and uniformity of the synthesized NPs. These parameters also have influence on crystal phase and luminescence intensity of the NPs. Adjusting hydrothermal reaction time and dopant concentration also enable the synthesis of NPs with strong UC luminescence. The as-prepared UCNP showed cellular nontoxicity to HeLa cells, and thus they are capable as promising agents for biological imaging.

摘要

采用简便的水热法，制备了亲水性 NaYF:Yb/Er 纳米粒子（NPs）作为镧系掺杂上转换（UC）材料，其具有不同的形态、晶体相和发光强度。通过电子显微镜和光谱、X 射线衍射（XRD）和光致发光分析对 UCNP 进行了表征。反应物的摩尔浓度和 NaF 的体积影响合成 NPs 的形状和均匀性。这些参数对上转换纳米颗粒的晶体相和发光强度也有影响。通过调整水热反应时间和掺杂浓度，还可以合成具有强上转换发光的 NPs。所制备的 UCNP 对 HeLa 细胞表现出细胞无毒，因此它们有望成为生物成像的理想试剂。