Department of Chemistry, Universidad Nacional del Sur, B8000CPB Bahía Blanca, INQUISUR-CONICET, Argentina.
Department of Chemistry, Universidad Nacional del Sur, B8000CPB Bahía Blanca, INQUISUR-CONICET, Argentina.
Mater Sci Eng C Mater Biol Appl. 2019 Jun;99:180-190. doi: 10.1016/j.msec.2019.01.098. Epub 2019 Jan 23.
The use of high doses of antibacterial and anti-inflammatory drugs for patients with bone diseases, associated to implants or bone filling, can develop adverse effects; and consequently, it promotes to think new strategies to avoid this problem. In this work, it has been described the adsorption/release (or desorption) behavior of two drugs, ciprofloxacin (CIP) and ibuprofen (IBU), onto hydroxyapatite (nano-HA) at 37 °C. Through Ultraviolet-Visible (UV-Vis) spectroscopy, the concentrations of both drugs in adsorption, kinetic and desorption processes were obtained. The Fourier Transformed-Infrared (FT-IR) spectroscopy, Zeta-potential (ζ-potential), High-Resolution Transmission Electron Microscopy (H-TEM) and x-Ray Diffraction (xRD) were also used to characterize bared nanoparticles and those with adsorbed drugs. Five adsorption models (Langmuir, Freundlich, Sips, Temkin and Dubinin-Radushkevich) were used for describing the behavior of both active compounds. The adsorption processes (CIP/nano-HA and IBU/nano-HA) were better predicted by the Sips model than by the others. The kinetic adsorption data were processed, for both active agents, by application of Avrami's model. Desorption/release process (of both drugs) was evaluated though Korsmeyer-Peppas (K-P) model. Owing to the predictability of these systems, we propose the use of these active ceramics as potential bone filler for improving the treatment against bacterial bone infections and to avoid its associated inflammatory process.
对于患有骨病、与植入物或骨填充物相关的患者，使用大剂量的抗菌和抗炎药物会产生不良反应；因此，需要考虑新的策略来避免这个问题。在这项工作中，描述了两种药物（环丙沙星（CIP）和布洛芬（IBU））在 37°C 下在羟基磷灰石（纳米-HA）上的吸附/释放（或解吸）行为。通过紫外可见（UV-Vis）光谱法，获得了吸附、动力学和解吸过程中两种药物的浓度。傅里叶变换红外（FT-IR）光谱、Zeta 电位（ζ-电位）、高分辨率透射电子显微镜（H-TEM）和 x 射线衍射（xRD）也用于表征裸露的纳米颗粒和吸附药物的纳米颗粒。使用了五种吸附模型（朗缪尔、弗伦德利希、Sips、Temkin 和 Dubinin-Radushkevich）来描述两种活性化合物的行为。对于两种活性化合物，吸附过程（CIP/纳米-HA 和 IBU/纳米-HA）都更符合 Sips 模型的预测。对于两种活性物质，通过应用 Avrami 模型对吸附动力学数据进行了处理。通过 Korsmeyer-Peppas（K-P）模型评估了脱附和释放过程（两种药物）。鉴于这些系统的可预测性，我们建议使用这些活性陶瓷作为潜在的骨填充物，以改善对细菌性骨感染的治疗，并避免其相关的炎症过程。
