Moore M C, Greene H L, Donald W D, Dunn G D
Am J Clin Nutr. 1986 Jul;44(1):33-41. doi: 10.1093/ajcn/44.1.33.
Eight children (aged 8 mo to 13 yr) with cystic fibrosis (CF) and growth failure were given home nocturnal nasogastric feeding of an elemental diet for 3 mo and re-evaluated 3 mo after cessation of tube feeding. An increase in energy intake (p less than 0.05) resulted in increased serum transferrin (p less than 0.005), retinol-binding protein (p less than 0.05), and clinical scores (p less than 0.05) during the study. Height and growth velocity increased by 60% (p less than 0.05), and weight growth velocity increased by 63%. Arm-muscle circumference, triceps skinfolds, serum albumin, vitamin A, vitamin E, zinc, and copper did not change significantly during tube feeding. Nocturnal feeding were safe and effective in promoting growth; however, most children with severe lung disease did not sustain the gains after cessation of tube feeding. Our findings indicate that continued nutritional support is needed to maintain the growth in malnourished children with severe lung disease.
八名患有囊性纤维化（CF）且生长发育迟缓的儿童（年龄在8个月至13岁之间）接受了为期3个月的夜间家庭鼻饲要素饮食，并在停止管饲后3个月进行了重新评估。在研究期间，能量摄入增加（p<0.05）导致血清转铁蛋白（p<0.005）、视黄醇结合蛋白（p<0.05）和临床评分（p<0.05）升高。身高和生长速度增加了60%（p<0.05），体重增长速度增加了63%。在管饲期间，上臂肌肉周长、三头肌皮褶厚度、血清白蛋白、维生素A、维生素E、锌和铜没有显著变化。夜间喂养在促进生长方面是安全有效的；然而，大多数患有严重肺部疾病的儿童在停止管饲后无法维持生长发育的改善。我们的研究结果表明，需要持续的营养支持来维持患有严重肺部疾病的营养不良儿童的生长发育。
