Bertrand J M, Morin C L, Lasalle R, Patrick J, Coates A L
J Pediatr. 1984 Jan;104(1):41-6. doi: 10.1016/s0022-3476(84)80586-7.
Ten children with cystic fibrosis, aged 3.5 to 12 years, whose weights were lower than 90% of the expected weight for height, received high-calorie elemental enteral alimentation for four weeks. Clinical, anthropometric, and biochemical evaluations as well as blood gas analyses and chest radiograph scoring were performed in all. Pulmonary function tests were performed in the five older children, and progressive exercise tests in three. These evaluations were done before, immediately after, and two months after termination of therapy. Nutritional therapy resulted in an increase of caloric intake and in dramatic weight gain, which persisted only for a short time and was mainly related to adipose tissue accretion. No functional improvement accompanied the amelioration in nutritional status. This short-term nutritional therapy in malnourished children with cystic fibrosis was effective in increasing relative weight and energy stores, but there was no evidence of any long-term functional benefit.
10名患有囊性纤维化的儿童，年龄在3.5至12岁之间，体重低于身高预期体重的90%，接受了四周的高热量要素肠内营养。对所有儿童都进行了临床、人体测量学和生化评估以及血气分析和胸部X线评分。对5名年龄较大的儿童进行了肺功能测试，对3名儿童进行了渐进性运动测试。这些评估在治疗开始前、治疗结束后立即以及治疗结束后两个月进行。营养治疗导致热量摄入增加和体重显著增加，但这种增加仅持续了很短时间，且主要与脂肪组织堆积有关。营养状况改善的同时并未伴随功能改善。对营养不良的囊性纤维化儿童进行的这种短期营养治疗有效地增加了相对体重和能量储备，但没有证据表明有任何长期功能益处。
