Sani Anis, Tajik Ali, Seiiedi Seiied Sina, Khadem Razieh, Tootooni Haniye, Taherynejad Mohammadhossein, Sabet Eqlidi Nasim, Alavi Dana Seyyed Mohammad Matin, Deravi Niloofar
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Nutr Metab Insights. 2022 Jul 27;15:11786388221095223. doi: 10.1177/11786388221095223. eCollection 2022.
Diabetes mellitus is one of the most prevalent metabolic disorders that affect people of all genders, ages, and races. Medicinal herbs have gained attention from researchers and have been widely investigated for their antidiabetic potential. Saffron ( L.) and its main constituents, that is, crocin and crocetin, are natural carotenoid compounds, widely known to possess a wide spectrum of properties and induce pleiotropic anti-inflammatory, anti-oxidative, and neuro-protective effects. An increasing number of experimental, animal and human studies have investigated the effects and mechanism of action of these compounds and their potential therapeutic use in the treatment of diabetes. This narrative review presents the key findings of published clinical studies that examined the effects of saffron and/or its constituents in the context of diabetes mellitus. Moreover, an overview of the proposed underlying mechanisms mediating these effects, the medicinal applications of saffron, and the new findings regarding its effect on diabetes and various cellular and molecular mechanisms of action will be debated.
糖尿病是最常见的代谢紊乱疾病之一，影响着所有性别、年龄和种族的人群。草药已引起研究人员的关注，并因其抗糖尿病潜力而受到广泛研究。藏红花及其主要成分，即藏花素和藏红花酸，是天然类胡萝卜素化合物，众所周知具有广泛的特性，并能产生多效抗炎、抗氧化和神经保护作用。越来越多的实验、动物和人体研究调查了这些化合物的作用效果和作用机制，以及它们在糖尿病治疗中的潜在治疗用途。本叙述性综述介绍了已发表的临床研究的主要发现，这些研究考察了藏红花及其成分在糖尿病背景下的作用。此外，还将讨论介导这些作用的潜在机制、藏红花的药用应用，以及关于其对糖尿病的影响和各种细胞与分子作用机制的新发现。
