Buetow K H, Chakravarti A
Am J Hum Genet. 1987 Aug;41(2):189-201.
Seriation methods provide an accurate and efficient means of constructing preliminary multilocus genetic maps. By using both simulated and previously published empirical data, multipoint mapping by seriation was critically evaluated. Analysis of the simulated data sets showed that the seriation methodology could accurately estimate order and interlocus distances. Application to the empirical data demonstrated that seriation could obtain results directly comparable with those of other multipoint mapping methods. Techniques such as seriation can produce preliminary genetic maps that may be used as starting points for more computer-intensive maximum-likelihood multipoint techniques.
序列化方法为构建初步的多位点遗传图谱提供了一种准确且高效的手段。通过使用模拟数据和先前发表的实证数据，对序列化多点映射进行了严格评估。对模拟数据集的分析表明，序列化方法能够准确估计基因座顺序和基因座间距离。应用于实证数据表明，序列化能够获得与其他多点映射方法直接可比的结果。诸如序列化之类的技术可以生成初步的遗传图谱，这些图谱可用作更耗费计算机资源的最大似然多点技术的起点。
