Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
School of Pharmacy, Bandung Institute of Technology, Jl. Ganesha 10, Bandung 40132, Indonesia.
Mar Drugs. 2019 Mar 18;17(3):176. doi: 10.3390/md17030176.
Six new phenalenone derivatives (⁻), along with five known compounds (⁻) of the herqueinone class, were isolated from a marine-derived fungus sp. The absolute configurations of these compounds were assigned based on chemical modifications and their specific rotations. 4-Hydroxysclerodin () and an acetone adduct of a triketone () exhibited moderate anti-angiogenetic and anti-inflammatory activities, respectively, while -peniciherqueinone () and isoherqueinone () exhibited moderate abilities to induce adipogenesis without cytotoxicity.
从海洋来源真菌 sp. 中分离得到 6 种新的菲咯啉酮衍生物（⁻）和 5 种已知的赫醌类化合物（⁻）。这些化合物的绝对构型是根据化学修饰和比旋光度确定的。4-羟基雪根醇（）和三酮（）的丙酮加成物分别表现出中等的抗血管生成和抗炎活性，而 -peniciherqueinone（）和异赫醌（）则表现出中等的诱导脂肪生成能力而无细胞毒性。
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