1 Department of Biomedical Engineering, Columbia University, New York, NY 10032, USA.
2 Department of Medicine, Columbia University, New York NY 10032, USA.
Exp Biol Med (Maywood). 2019 May;244(8):630-645. doi: 10.1177/1535370219834498. Epub 2019 Mar 19.
Over the past several decades, ex vivo perfusion has emerged as a promising technology for the assessment, preservation, and recovery of donor organs. Many exciting pre-clinical findings have now been translated to clinical use, and successful transplantation following ex vivo perfusion has been achieved for heart, lung, and liver. While machine perfusion provides distinct advantages over traditional cold preservation, many challenges remain, including that of long-term (multi-day) ex vivo support. Here, we provide an overview of the current status of ex vivo machine perfusion in the pre-clinical and clinical setting and share our perspective on the future direction of the field.
在过去的几十年中，体外灌注技术作为一种评估、保存和恢复供体器官的有前途的技术已经出现。许多令人兴奋的临床前发现现在已经转化为临床应用，并且已经成功地对心脏、肺和肝脏进行了体外灌注后的移植。虽然机器灌注提供了优于传统冷藏保存的明显优势，但仍存在许多挑战，包括长期（多日）的体外支持。在这里，我们提供了体外机器灌注在临床前和临床环境中的当前状态概述，并分享了我们对该领域未来方向的看法。
