Fordham University, Department of Psychology, Bronx, New York.
Institute of Human Nutrition, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York.
J Int Neuropsychol Soc. 2019 Aug;25(7):668-677. doi: 10.1017/S1355617719000055.
Insomnia is associated with neuropsychological dysfunction. Evidence points to the role of nocturnal light exposure in disrupted sleep patterns, particularly blue light emitted through smartphones and computers used before bedtime. This study aimed to test whether blocking nocturnal blue light improves neuropsychological function in individuals with insomnia symptoms.
This study used a randomized, placebo-controlled crossover design. Participants were randomly assigned to a 1-week intervention with amber lenses worn in wrap-around frames (to block blue light) or a 1-week intervention with clear lenses (control) and switched conditions after a 4-week washout period. Neuropsychological function was evaluated with tests from the NIH Toolbox Cognition Battery at three time points: (1) baseline (BL), (2) following the amber lenses intervention, and (3) following the clear lenses intervention. Within-subjects general linear models contrasted neuropsychological test performance following the amber lenses and clear lenses conditions with BL performance.
Fourteen participants (mean(standard deviation, SD): age = 46.5(11.4)) with symptoms of insomnia completed the protocol. Compared with BL, individuals performed better on the List Sorting Working Memory task after the amber lenses intervention, but similarly after the clear lenses intervention (F = 5.16; p = .014; η2 = 0.301). A similar pattern emerged on the Pattern Comparison Processing Speed test (F = 7.65; p = 0.002; η2 = 0.370). Consideration of intellectual ability indicated that treatment with amber lenses "normalized" performance on each test from approximately 1 SD below expected performance to expected performance.
Using a randomized, placebo-controlled crossover design, we demonstrated improvement in processing speed and working memory with a nocturnal blue light blocking intervention among individuals with insomnia symptoms. (JINS, 2019, 25, 668-677).
失眠与神经认知功能障碍有关。有证据表明，夜间光照暴露会破坏睡眠模式，尤其是睡前使用智能手机和电脑发出的蓝光。本研究旨在测试夜间蓝光阻断是否能改善有失眠症状个体的神经认知功能。
本研究采用随机、安慰剂对照交叉设计。参与者被随机分配到为期 1 周的干预组，佩戴全包围镜框的琥珀色镜片（阻断蓝光）或为期 1 周的对照组（佩戴透明镜片），并在 4 周洗脱期后切换条件。使用 NIH 工具包认知电池中的测试在三个时间点评估神经认知功能：（1）基线（BL），（2）佩戴琥珀色镜片干预后，以及（3）佩戴透明镜片干预后。在主体内的一般线性模型中，使用对比分析在佩戴琥珀色和透明镜片条件下的神经认知测试表现与 BL 表现的差异。
14 名有失眠症状的参与者（平均（标准差，SD）：年龄=46.5（11.4））完成了方案。与 BL 相比，在佩戴琥珀色镜片干预后，个体在列表排序工作记忆任务上的表现更好，但在佩戴透明镜片干预后表现类似（F=5.16；p=0.014；η2=0.301）。在模式比较处理速度测试中也出现了类似的模式（F=7.65；p=0.002；η2=0.370）。考虑智力能力后，表明佩戴琥珀色镜片的治疗使每个测试的表现从低于预期表现约 1 个标准差“正常化”到预期表现。
使用随机、安慰剂对照交叉设计，我们在有失眠症状的个体中证明了夜间蓝光阻断干预可改善处理速度和工作记忆。（JINS，2019，25，668-677）。
