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在记忆巩固过程中急性暴露于蓝光波长光可改善言语记忆表现。

Acute exposure to blue wavelength light during memory consolidation improves verbal memory performance.

作者信息

Alkozei Anna, Smith Ryan, Dailey Natalie S, Bajaj Sahil, Killgore William D S

机构信息

Department of Psychiatry, University of Arizona College of Medicine, Tucson, Arizona, United States of America.

出版信息

PLoS One. 2017 Sep 18;12(9):e0184884. doi: 10.1371/journal.pone.0184884. eCollection 2017.

Abstract

Acute exposure to light within the blue wavelengths has been shown to enhance alertness and vigilance, and lead to improved speed on reaction time tasks, possibly due to activation of the noradrenergic system. It remains unclear, however, whether the effects of blue light extend beyond simple alertness processes to also enhance other aspects of cognition, such as memory performance. The aim of this study was to investigate the effects of a thirty minute pulse of blue light versus placebo (amber light) exposure in healthy normally rested individuals in the morning during verbal memory consolidation (i.e., 1.5 hours after memory acquisition) using an abbreviated version of the California Verbal Learning Test (CVLT-II). At delayed recall, individuals who received blue light (n = 12) during the consolidation period showed significantly better long-delay verbal recall than individuals who received amber light exposure (n = 18), while controlling for the effects of general intelligence, depressive symptoms and habitual wake time. These findings extend previous work demonstrating the effect of blue light on brain activation and alertness to further demonstrate its effectiveness at facilitating better memory consolidation and subsequent retention of verbal material. Although preliminary, these findings point to a potential application of blue wavelength light to optimize memory performance in healthy populations. It remains to be determined whether blue light exposure may also enhance performance in clinical populations with memory deficits.

摘要

研究表明,急性暴露于蓝光波长范围内的光线可提高警觉性和 vigilance ,并加快反应时间任务的速度,这可能是由于去甲肾上腺素能系统的激活所致。然而,蓝光的作用是否超出简单的警觉过程,还能增强认知的其他方面,如记忆表现,仍不清楚。本研究的目的是使用加利福尼亚言语学习测试(CVLT-II)的简化版,调查在早晨言语记忆巩固期间(即记忆获取后1.5小时),对健康且正常休息的个体进行30分钟蓝光脉冲照射与安慰剂(琥珀光)照射的效果。在延迟回忆时,在巩固期接受蓝光照射的个体(n = 12)在长延迟言语回忆方面显著优于接受琥珀光照射的个体(n = 18),同时控制了一般智力、抑郁症状和习惯性起床时间的影响。这些发现扩展了先前关于蓝光对大脑激活和警觉性影响的研究,进一步证明了其在促进更好的记忆巩固和随后言语材料保留方面的有效性。尽管这些发现是初步的,但它们指出了蓝光波长光在优化健康人群记忆表现方面的潜在应用。蓝光照射是否也能提高有记忆缺陷的临床人群的表现,仍有待确定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d738/5602660/8395a61aa142/pone.0184884.g001.jpg

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