Collin R I, Drummond G B, Spence A A
Anaesthesia. 1986 May;41(5):477-81. doi: 10.1111/j.1365-2044.1986.tb13270.x.
Thirty-nine unpremedicated patients who presented for cystoscopy were given either alfentanil or saline in a random double-blind fashion immediately before anaesthesia with etomidate, nitrous oxide and enflurane. Alfentanil significantly reduced myoclonus associated with etomidate. During anaesthesia, patients who received alfentanil had smaller minute volumes, lower respiratory frequencies, and smaller increases in heart rate. The incidence of apnoea was not significantly increased. After operation, patients who received alfentanil were prescribed significantly more analgesia, possibly because of their reduced uptake of volatile anaesthetic agent. It is concluded that supplementation with alfentanil improves the quality of anaesthesia induced with etomidate.
39例接受膀胱镜检查且未预先用药的患者，在使用依托咪酯、氧化亚氮和恩氟烷麻醉前，以随机双盲方式给予阿芬太尼或生理盐水。阿芬太尼显著减少了与依托咪酯相关的肌阵挛。麻醉期间，接受阿芬太尼的患者每分通气量较小、呼吸频率较低，心率增幅也较小。呼吸暂停的发生率没有显著增加。术后，接受阿芬太尼的患者需要显著更多的镇痛药物，这可能是因为他们对挥发性麻醉剂的摄取减少。结论是，补充阿芬太尼可提高依托咪酯诱导麻醉的质量。
