Sanders R S, Sinclair M E, Sear J W
Anaesthesia. 1984 Dec;39(12):1202-6. doi: 10.1111/j.1365-2044.1984.tb06432.x.
Ninety patients, premedicated with temazepam 20 mg, undergoing suction termination of pregnancy, were studied. Forty patients received alfentanil (500 micrograms), and thirty halothane (1.5%) as supplements to either etomidate or methohexitone-nitrous oxide-oxygen anaesthesia. A further 20 patients received alfentanil 250 micrograms at induction of anaesthesia with methohexitone, followed by a further 250 micrograms immediately prior to the onset of surgery. Recovery was assessed by the time patients took to open eyes on command, to giving their correct date of birth, and to performing the 'p' deletion test. Satisfactory operating conditions were not obtained with the combination of etomidate and halothane. Faster recovery was seen in patients with either etomidate or methohexitone and receiving alfentanil (p less than 0.01) Testing by the 'p' deletion test showed impaired psychomotor performance at 30 minutes after cessation of anaesthesia in all groups compared with the pre-operative scores. Side effects leading to unsatisfactory anaesthesia were more frequent in patients who had received etomidate (p less than 0.01).
对90例接受了20mg替马西泮预处理、正在进行负压吸引终止妊娠的患者进行了研究。40例患者接受阿芬太尼（500微克），30例接受氟烷（1.5%），作为依托咪酯或甲己炔巴比妥-氧化亚氮-氧气麻醉的补充。另外20例患者在甲己炔巴比妥麻醉诱导时接受250微克阿芬太尼，然后在手术开始前立即再给予250微克。通过患者按指令睁眼的时间、说出正确出生日期的时间以及进行“p”删除试验的时间来评估恢复情况。依托咪酯和氟烷联合使用未获得满意的手术条件。接受阿芬太尼的依托咪酯或甲己炔巴比妥患者恢复更快（p<0.01）。与术前评分相比，所有组在麻醉停止后30分钟通过“p”删除试验测试显示精神运动表现受损。接受依托咪酯的患者中导致麻醉不满意的副作用更常见（p<0.01）。
