Li Xiao, Meng Huaqing, Fu Yixiao, Du Lian, Qiu Haitang, Qiu Tian, Chen Qibin, Zhang Zhiwei, Luo Qinghua
Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Front Psychiatry. 2019 Mar 1;10:7. doi: 10.3389/fpsyt.2019.00007. eCollection 2019.
To explore the alteration of global functional connectivity density (gFCD) in depressive patients after modified electroconvulsive therapy (MECT) and analyze the relationship between gFCD and clinical outcome. Thirty-seven subjects were evaluated based on the diagnostic criteria of the International Classification of Diseases-10 (ICD-10), consisting of a depressive group (24 patients after follow-ups) and a healthy control group with 13 normal individuals. All participants received Hamilton Depression Scale (HAMD) scores and resting-state functional magnetic resonance imaging scans. The gFCD significantly increased in the posterior-middle insula, the supra-marginal gyrus and the dorsal medial prefrontal cortex (dmPFC) before MECT treatment compared to healthy controlled patients. The gFCD statistically expanded in the perigenual anterior cingulate cortex (pgACC), the orbitofrontal cortex bilaterally and the left-supra-marginal gyrus after MECT, and it decreased notably in the posterior insula. The gFCD in the pgACC and the right orbital frontal cortex of depressive group before MECT showed a positive correlation with HAMD scores with treatment. Conforming to the impact of gFCD in depressive patients after MECT, the aforementioned brain region may become an indicator of MECT effect.
探讨改良电休克治疗（MECT）后抑郁症患者全脑功能连接密度（gFCD）的变化，并分析gFCD与临床疗效之间的关系。根据国际疾病分类第10版（ICD-10）的诊断标准对37名受试者进行评估，包括一个抑郁症组（随访后24例患者）和一个由13名正常个体组成的健康对照组。所有参与者均接受汉密尔顿抑郁量表（HAMD）评分及静息态功能磁共振成像扫描。与健康对照患者相比，MECT治疗前抑郁症患者脑岛中后部、缘上回和背内侧前额叶皮质（dmPFC）的gFCD显著增加。MECT治疗后，膝周前扣带回皮质（pgACC）、双侧眶额皮质和左侧缘上回的gFCD在统计学上扩大，而脑岛后部的gFCD显著降低。抑郁症组MECT治疗前pgACC和右侧眶额皮质的gFCD与治疗后的HAMD评分呈正相关。符合MECT治疗后抑郁症患者gFCD的影响，上述脑区可能成为MECT疗效的一个指标。
