Department of Virology, Student Research Committee, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Brujen, Iran.
J Cell Physiol. 2019 Aug;234(10):17064-17099. doi: 10.1002/jcp.28457. Epub 2019 Mar 19.
Cervical cancer is as a kind of cancer beginning from the cervix. Given that cervical cancer could be observed in women who infected with papillomavirus, regular oral contraceptives, and multiple pregnancies. Early detection of cervical cancer is one of the most important aspects of the therapy of this malignancy. Despite several efforts, finding and developing new biomarkers for cervical cancer diagnosis are required. Among various prognostic, diagnostic, and therapeutic biomarkers, miRNA have been emerged as powerful biomarkers for detection, treatment, and monitoring of response to therapy in cervical cancer. Here, we summarized various miRNAs as an employable platform for prognostic, diagnostic, and therapeutic biomarkers in the treatment of cervical cancer.
宫颈癌是一种起源于子宫颈的癌症。鉴于宫颈癌可发生于感染人乳头瘤病毒、经常服用口服避孕药和多次怀孕的女性,因此,宫颈癌的早期发现是治疗这种恶性肿瘤的最重要方面之一。尽管已经做了很多努力,但仍需要寻找和开发用于宫颈癌诊断的新生物标志物。在各种预后、诊断和治疗生物标志物中,miRNA 已成为宫颈癌检测、治疗和监测治疗反应的有力生物标志物。在这里,我们总结了各种 miRNA 作为宫颈癌治疗中预后、诊断和治疗生物标志物的一种可行平台。