Atatürk University, Faculty of Dentistry, Department of Endodontics, Erzurum, Turkey.
Sağlık Bilimleri University, Faculty of Dentistry,Department of Periodontology, Istanbul, Turkey.
Braz Oral Res. 2019 Mar 18;32:e125. doi: 10.1590/1807-3107bor-2018.vol32.0125.
The aim of this study was to investigate the effect of a placebo, intracanal diode laser application, and low-level laser therapy (LLLT) on the change of the total amount of calcitonin gene-related peptide (CGRP) in the gingival crevicular fluid (GCF) (split-mouth study design). GCF sampling was performed on a contralateral tooth and experimental tooth (root canal-treated tooth) of thirty-nine patients. The patients were divided into three groups (n = 13), as follows: placebo (mock laser application), intracanal laser application, and LLLT. GCF sampling was repeated at the same sites (experimental and control teeth) one week after root canal treatment. The data were analyzed using the Pearson's correlation analysis and the independent-samples t-tests (p=0.05). In the placebo group, the total CGRP level changes in the GCF before and after treatment was significantly higher for experimental teeth than for control teeth (p<0.05). However, there was no significant difference between experimental and control teeth in the intracanal laser application and LLLT groups (p > 0.05). Intracanal laser application and low-level laser therapy have immunomodulation effects linked to the modulation of the total amount of CGRP in the GCF.
本研究旨在探讨安慰剂、根管内二极管激光应用和低水平激光治疗（LLLT）对龈沟液（GCF）中降钙素基因相关肽（CGRP）总量变化的影响（分侧研究设计）。在 39 名患者的对侧牙和实验牙（根管治疗牙）上进行 GCF 采样。将患者分为三组（n = 13），如下：安慰剂（模拟激光应用）、根管内激光应用和 LLLT。根管治疗后一周，在相同部位（实验牙和对照牙）重复进行 GCF 采样。使用 Pearson 相关分析和独立样本 t 检验（p=0.05）分析数据。在安慰剂组中，治疗前后 GCF 中 CGRP 总量的变化在实验牙上明显高于对照牙（p<0.05）。然而，在根管内激光应用和 LLLT 组中，实验牙和对照牙之间没有显著差异（p > 0.05）。根管内激光应用和低水平激光治疗具有与 GCF 中 CGRP 总量调节相关的免疫调节作用。
