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LILRB1 基因而非 LILRA3 基因多态性对强直性脊柱炎免疫病理学的影响-与 KIR 基因平行。

The effect of LILRB1 but not LILRA3 gene polymorphism in immunopathology of ankylosing spondylitis-A parallel to KIR genes.

机构信息

Department of Clinical Immunology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.

Department of Biochemistry and Physiology, Faculty of Physical Education and Physiotherapy, Institute of Physiotherapy, Opole University of Technology, Opole, Poland.

出版信息

Int J Immunogenet. 2019 Jun;46(3):146-151. doi: 10.1111/iji.12422. Epub 2019 Mar 20.

DOI:10.1111/iji.12422
PMID:30892832
Abstract

LILR and KIR receptors recognize HLA-B27 and may influence immune response in ankylosing spondylitis (AS) development. Purpose of the study was to analyse LILRB1/LILRA3 polymorphisms in AS. We observed a possible protective effect of the T allele of LILRB1 rs1061680:T>C and no association with insertion/deletion polymorphisms of LILRA3 with AS.

摘要

LILR 和 KIR 受体识别 HLA-B27，可能影响强直性脊柱炎 (AS) 发展中的免疫反应。本研究旨在分析 AS 中 LILRB1/LILRA3 多态性。我们观察到 LILRB1 rs1061680:T>C 中的 T 等位基因可能具有保护作用，而 LILRA3 的插入/缺失多态性与 AS 无关。

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