可视化视网膜小胶质细胞的异质性。
Visualizing the Heterogeneity of Retinal Microglia.
机构信息
Department of Ophthalmology & Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA.
Department of Ophthalmology & Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.
出版信息
Immunity. 2019 Mar 19;50(3):544-546. doi: 10.1016/j.immuni.2019.02.017.
Abstract
In this issue of Immunity, O'Koren et al. (2019) report that murine retinal microglia are long lived and are divided into two spatially and functionally distinct niches in the retina. In models of retinal neurodegeneration, retinal microglia migrate to the subretinal space, an inducible disease-associated niche, where they are neuroprotective.
摘要
在本期《免疫》中，O'Koren 等人（2019 年）报告称，鼠类视网膜小胶质细胞寿命长，并在视网膜中分为两个空间和功能上不同的龛位。在视网膜神经退行性变模型中，视网膜小胶质细胞迁移到视网膜下腔，即一个可诱导的与疾病相关的龛位，在那里它们具有神经保护作用。
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Oxysterol Signatures Distinguish Age-Related Macular Degeneration from Physiologic Aging.氧化固醇特征可区分年龄相关性黄斑变性与生理性衰老。
EBioMedicine. 2018 Jun;32:9-20. doi: 10.1016/j.ebiom.2018.05.035. Epub 2018 Jun 11.
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Macrophage microRNA-150 promotes pathological angiogenesis as seen in age-related macular degeneration.巨噬细胞 microRNA-150 促进年龄相关性黄斑变性中的病理性血管生成。
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