外泌体在化疗过程中抑制抗肿瘤免疫。

Exosomes Exercise Inhibition of Anti-Tumor Immunity during Chemotherapy.

机构信息

Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA; Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.

出版信息

Immunity. 2019 Mar 19;50(3):547-549. doi: 10.1016/j.immuni.2019.02.019.

DOI:10.1016/j.immuni.2019.02.019

PMID:30893584

Abstract

Exosomes are nano-sized extracellular vesicles that contain DNA, RNA, proteins, and lipids. Exosomes likely participate in facilitating intercellular communication and tumor growth. In this issue of Immunity, Zhang et al. (2019) report on the metabolic activity of B cell-derived exosomes in facilitating the suppression of cytotoxic T cells.

摘要

外泌体是一种纳米大小的细胞外囊泡，其内含有 DNA、RNA、蛋白质和脂质。外泌体可能参与了促进细胞间通讯和肿瘤生长的过程。在本期《免疫》杂志中，Zhang 等人（2019）报道了 B 细胞来源的外泌体的代谢活性在促进细胞毒性 T 细胞抑制中的作用。