Zhang Runmin, Li Muzhe, Li Huiyun, Ran Xun, Jin Fengtian, Tan Qingshan, Chen Zhiwei
Department of Orthopaedics, The First Affiliated Hospital of University of South China, Hengyang, People's Republic of China.
J Inflamm Res. 2024 Jan 17;17:301-312. doi: 10.2147/JIR.S421649. eCollection 2024.
Inflammation is a common feature of many inflammatory diseases and tumors, and plays a decisive role in their development. Exosomes are extracellular vesicles unleashed by assorted types of cells, and it is widely known that exosomes of different immune cell sources play different functions. Exosome production has recently been reported for immune cells comprising macrophages, T cells, B cells, and dendritic cells (DCs). Immune cell-derived exosomes are involved in a variety of inflammatory responses.Herein, we summarize and review the role of macrophages, T cells, B cells, and dendritic cells (DC) in inflammatory diseases, with a focus on the role of immune cell-derived exosomes in osteoarthritis, rheumatoid arthritis, and the inflammatory tumor microenvironment (TME).These findings are expected to be important for developing new treatments for inflammatory diseases and ameliorating tumor-related inflammation.
炎症是许多炎症性疾病和肿瘤的共同特征，在其发展过程中起决定性作用。外泌体是由各种类型的细胞释放的细胞外囊泡，众所周知，不同免疫细胞来源的外泌体具有不同的功能。最近有报道称，包括巨噬细胞、T细胞、B细胞和树突状细胞（DC）在内的免疫细胞可产生外泌体。免疫细胞衍生的外泌体参与多种炎症反应。在此，我们总结并综述了巨噬细胞、T细胞、B细胞和树突状细胞（DC）在炎症性疾病中的作用，重点关注免疫细胞衍生的外泌体在骨关节炎、类风湿性关节炎和炎症性肿瘤微环境（TME）中的作用。这些发现有望对开发炎症性疾病的新疗法和改善肿瘤相关炎症具有重要意义。
