Department of Biological Sciences, Universidade Estadual de Santa Cruz, BR-415, Rodovia Ilhéus- Itabuna, Km-16, Salobrinho, Ilhéus, Bahia, 45662-000, Brazil.
Faculdade de Ciências da Saúde, Universidade Braz Cubas, São Paulo, Brazil.
BMC Complement Altern Med. 2019 Mar 20;19(1):72. doi: 10.1186/s12906-019-2478-8.
Solidago chilensis (syn. microglossa) is a plant from the Asteraceae family widely distributed in South America and used to treat inflammatory diseases. In 2009, it was listed as one of the native medicinal herbal plants used in the Brazilian public health system. In addition to its anti-inflammatory properties, a recent clinical study has shown antinociceptive effects of S. chilensis, introducing a new potential medical use for this plant. The aim of the present study was to investigate the antinociceptive activity of the hydroalcoholic extract of Solidago chilensis (HESc) in rodent models of pain.
The dried plant extract was obtained from its aerial parts, maintained in ethanol (100 g/l) and filtered. Rats or mice were treated with intraperitoneal injections of HESc (3, 10 or 30 mg/kg) 30 min before being submitted to writhing, 0.2%-formaline or hot-plate tests or prostaglandin E (PGE) administration in the hind paw. Mechanical hypernociception and motor impairment were evaluated by electronic von Frey and rota-rod, respectively.
HESc dose-dependently inhibited abdominal contortions in the writhing test and attenuated phases I and II formalin-induced nociceptive behavior. Treatment with HESc also increased thermal threshold and decreased PGE-induced hypernociception without promoting motor impairment.
Our data suggest that, when systemically administered, HESc decreases nociception without inducing a sedative effect. Importantly, this effect was observed in both inflammatory and non-inflammatory models of pain and nociception, suggesting a specific non-inflammatory mechanism of HESc on pain. Our findings indicate that S. chilensis might be an important adjuvant in pain management.
Solidago chilensis（同义词 microglossa）是一种来自 Asteraceae 科的植物，广泛分布于南美洲，用于治疗炎症性疾病。2009 年，它被列为巴西公共卫生系统中使用的本土药用植物之一。除了具有抗炎特性外，最近的一项临床研究表明 Solidago chilensis 具有抗伤害感受作用，为这种植物提供了新的潜在医学用途。本研究旨在研究 Solidago chilensis（HESc）水醇提取物在啮齿动物疼痛模型中的镇痛活性。
将干燥的植物提取物从其地上部分获得，保存在乙醇（100g/l）中并过滤。大鼠或小鼠在接受扭体、0.2%-甲醛或热板试验或后爪前列腺素 E（PGE）给药之前，接受腹腔内注射 HESc（3、10 或 30mg/kg）30 分钟。通过电子 von Frey 和旋转棒分别评估机械性痛觉过敏和运动障碍。
HESc 剂量依赖性地抑制扭体试验中的腹部扭曲，并减轻甲醛诱导的疼痛行为的 I 期和 II 期。HESc 治疗还增加了热阈值，并降低了 PGE 诱导的痛觉过敏，而没有促进运动障碍。
我们的数据表明，当系统给予时，HESc 可减轻疼痛而不引起镇静作用。重要的是，这种作用在炎症和非炎症性疼痛和伤害感受模型中均观察到，表明 HESc 对疼痛具有特定的非炎症性机制。我们的研究结果表明，S. chilensis 可能是疼痛管理的重要辅助药物。
