Laboratorio de Farmacognosia, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, Bahía Blanca, Buenos Aires, Argentina.
Pharm Biol. 2010 Sep;48(9):1025-30. doi: 10.3109/13880200903453131.
Solidago chilensis Meyen (Asteraceae) is widely used in South America in traditional medicine as an anti-inflammatory and diuretic, and to treat gastrointestinal disorders. However, no scientific evidence exists in literature to corroborate the therapeutic use of the plant. Despite its traditional uses, no reports are available on the safety of this utilization or on the relationship between the pharmacological activities and its phytochemical compounds.
This study investigates for the first time the acute toxicity and the gastroprotective effect of the aqueous extract from inflorescences of S. chilensis.
The gastroprotective activity was evaluated in mice subjected to ethanol-induced gastric ulcer model at 125, 250, 400, 800, 1200, and 2000 mg/kg doses. Acute toxicity study was performed at one dose of 2000 mg/kg. At the end of the exposure behavioral and functional parameters and motor activity were assessed in all animals.
Results demonstrated that the extract exhibited a significant antiulcer activity when given at 125-2000 mg/kg (P <0.05), but did not show acute toxicity in mice treated with 2000 mg/kg p.o.
This study demonstrated that the oral administration of S. chilensis aqueous extract prevents the formation of gastric lesions caused by an aggressive factor as ethanol but does not produce toxicity by acute exposure in mice. These promising results support a better pharmacological study of S. chilensis as a potential antiulcerogenic species for studies targeted towards the development of antiulcerogenic agents.
智利一枝黄花（菊科）在南美洲被广泛应用于传统医学，具有抗炎和利尿作用，可治疗胃肠道疾病。然而，文献中尚无科学证据证实该植物的治疗用途。尽管有传统用途，但尚无关于这种用途安全性的报告，也没有关于植物化学化合物与药理活性之间关系的报告。
本研究首次考察了智利一枝黄花花序的水提物的急性毒性和胃保护作用。
在 125、250、400、800、1200 和 2000mg/kg 剂量下，用乙醇诱导的胃溃疡模型评价胃保护活性。在一个 2000mg/kg 的剂量下进行急性毒性研究。在暴露结束时，对所有动物进行行为和功能参数以及运动活性的评估。
结果表明，该提取物在 125-2000mg/kg 时表现出显著的抗溃疡活性（P<0.05），但在经口给予 2000mg/kg 时，在小鼠中未显示出急性毒性。
本研究表明，智利一枝黄花水提物的口服给药可预防乙醇等侵袭性因素引起的胃损伤形成，但在急性暴露于小鼠时不会产生毒性。这些有前景的结果支持对智利一枝黄花进行更好的药理学研究，将其作为开发抗溃疡药物的潜在抗溃疡物种。
