Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY, United States.
Front Immunol. 2019 Mar 6;10:360. doi: 10.3389/fimmu.2019.00360. eCollection 2019.
Innate immunity is maintained in part by antigen presenting cells (APCs) including dendritic cells, macrophages, and B cells. APCs interact with T cells to link innate and adaptive immune responses. By displaying bacterial and tumorigenic antigens on their surface via major histocompatibility complexes, APCs can directly influence the differentiation of T cells. Likewise, T cell activation, differentiation, and effector functions are modulated by APCs utilizing multiple mechanisms. The objective of this review is to describe how APCs interact with and influence the activation of T cells to maintain innate immunity during exposure to microbial infection and malignant cells. How bacteria and cancer cells take advantage of some of these interactions for their own benefit will also be discussed. While this review will cover a broad range of topics, a general focus will be held around pathogens, cancers, and interactions that typically occur within the gastrointestinal tract.
先天免疫系统部分由抗原呈递细胞 (APCs) 维持，包括树突状细胞、巨噬细胞和 B 细胞。APCs 与 T 细胞相互作用，将先天免疫和适应性免疫反应联系起来。通过在其表面展示细菌和肿瘤抗原，通过主要组织相容性复合物，APCs 可以直接影响 T 细胞的分化。同样，T 细胞的激活、分化和效应功能也受到 APCs 通过多种机制的调节。本综述的目的是描述 APCs 如何与 T 细胞相互作用并影响其激活，以在暴露于微生物感染和恶性细胞时维持先天免疫。还将讨论细菌和癌细胞如何利用其中一些相互作用为自己谋取利益。虽然这篇综述将涵盖广泛的主题，但将重点放在病原体、癌症以及通常发生在胃肠道内的相互作用上。
