Department of Systems Immunology, Weizmann Institute of Science, Rehovot 76100, Israel.
Department of Cell Biology, New York University Grossman School of Medicine, New York, NY 10016, USA; Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, USA; Howard Hughes Medical Institute, New York, NY 10016, USA.
Immunity. 2024 Oct 8;57(10):2269-2279. doi: 10.1016/j.immuni.2024.09.011.
The immune system recognizes a multitude of innocuous antigens from food and intestinal commensal microbes toward which it orchestrates appropriate, non-inflammatory responses. This process requires antigen-presenting cells (APCs) that induce T cells with either regulatory or effector functions. Compromised APC function disrupts the T cell balance, leading to inflammation and dysbiosis. Although their precise identities continue to be debated, it has become clear that multiple APC lineages direct the differentiation of distinct microbiota-specific CD4 T cell programs. Here, we review how unique APC subsets instruct T cell differentiation and function in response to microbiota and dietary antigens. These discoveries provide new opportunities to investigate T cell-APC regulatory networks controlling immune homeostasis and perturbations associated with inflammatory and allergic diseases.
免疫系统识别来自食物和肠道共生微生物的多种无害抗原，并针对这些抗原协调适当的非炎症反应。这一过程需要抗原呈递细胞（APCs），它们诱导具有调节或效应功能的 T 细胞。APC 功能受损会破坏 T 细胞的平衡，导致炎症和微生态失调。尽管它们的确切身份仍存在争议，但已经清楚的是，多种 APC 谱系指导着不同的菌群特异性 CD4 T 细胞程序的分化。在这里，我们回顾了独特的 APC 亚群如何在响应微生物群和饮食抗原时指导 T 细胞的分化和功能。这些发现为研究控制免疫稳态的 T 细胞-APC 调节网络以及与炎症和过敏疾病相关的扰动提供了新的机会。
