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1
It is not justified to reject fertility treatment based on obesity.基于肥胖而拒绝生育治疗是不合理的。
Hum Reprod Open. 2017 Jul 28;2017(2):hox009. doi: 10.1093/hropen/hox009. eCollection 2017.
2
[Obesity: argument for withholding fertility treatment?].[肥胖症:反对进行生育治疗的理由?]
Ned Tijdschr Geneeskd. 2014;158:A7258.
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Economic consequences of overweight and obesity in infertility: a framework for evaluating the costs and outcomes of fertility care.超重和肥胖对不孕的经济影响:评估生育护理成本和结果的框架。
Hum Reprod Update. 2010 May-Jun;16(3):246-54. doi: 10.1093/humupd/dmp053. Epub 2010 Jan 7.
4
Pregnancy outcomes after assisted human reproduction.人类辅助生殖后的妊娠结局
J Obstet Gynaecol Can. 2014 Jan;36(1):64-83. doi: 10.1016/S1701-2163(15)30685-X.
5
The preconceptual contraception paradigm: obesity and infertility.孕前避孕模式:肥胖与不孕
Hum Reprod. 2007 Apr;22(4):912-5. doi: 10.1093/humrep/del473. Epub 2006 Dec 15.
6
Should access to fertility treatment be determined by female body mass index?女性的体重指数是否决定其是否能接受生育治疗?
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7
Obesity in pregnancy.妊娠期肥胖
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8
Maternal obesity and pregnancy.孕妇肥胖与妊娠
Postgrad Med. 2008 Sep 15;120(3):E01-9. doi: 10.3810/pgm.2008.09.1920.
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Female genital mutilation and cosmetic surgery: regulating non-therapeutic body modification.女性生殖器切割与整容手术:规范非治疗性身体改造
Bioethics. 1998 Oct;12(4):263-85. doi: 10.1111/1467-8519.00117.
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Severe maternal morbidity in women with high BMI in IVF and unassisted singleton pregnancies.体外受精和非辅助单胎妊娠中高 BMI 妇女的严重孕产妇发病率。
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Weight gain after in vitro fertilization: a potential consequence of controlled ovarian stimulation.体外受精后体重增加:控制性卵巢刺激的潜在后果。
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Irresponsibly Infertile? Obesity, Efficiency, and Exclusion from Treatment.不负责任地不育?肥胖、效率与治疗排除
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本文引用的文献

1
Randomized Trial of a Lifestyle Program in Obese Infertile Women.肥胖型不孕女性生活方式干预随机试验。
N Engl J Med. 2016 May 19;374(20):1942-53. doi: 10.1056/NEJMoa1505297.
2
Dropout is a problem in lifestyle intervention programs for overweight and obese infertile women: a systematic review.生活方式干预对超重和肥胖不孕女性的效果:系统评价。
Hum Reprod. 2013 Apr;28(4):979-86. doi: 10.1093/humrep/det026. Epub 2013 Feb 20.
3
Maternal diabetes in pregnancy: early and long-term outcomes on the offspring and the concept of "metabolic memory".孕期母亲糖尿病:对后代的早期和长期影响以及“代谢记忆”概念
Exp Diabetes Res. 2011;2011:218598. doi: 10.1155/2011/218598. Epub 2011 Nov 21.
4
Complications and outcome of assisted reproduction technologies in overweight and obese women.超重和肥胖女性的辅助生殖技术的并发症和结局。
Hum Reprod. 2012 Feb;27(2):457-67. doi: 10.1093/humrep/der416. Epub 2011 Dec 5.
5
Effect of body mass index on IVF treatment outcome: an updated systematic review and meta-analysis.体重指数对 IVF 治疗结局的影响:一项更新的系统评价和荟萃分析。
Reprod Biomed Online. 2011 Oct;23(4):421-39. doi: 10.1016/j.rbmo.2011.06.018. Epub 2011 Jul 28.
6
Timing of indicated late-preterm and early-term birth.指征性晚期早产儿和早期足月儿的分娩时机。
Obstet Gynecol. 2011 Aug;118(2 Pt 1):323-333. doi: 10.1097/AOG.0b013e3182255999.
7
Lifestyle-related factors and access to medically assisted reproduction.与生活方式相关的因素与医学辅助生殖的可及性。
Hum Reprod. 2010 Mar;25(3):578-83. doi: 10.1093/humrep/dep458. Epub 2010 Jan 18.
8
Economic consequences of overweight and obesity in infertility: a framework for evaluating the costs and outcomes of fertility care.超重和肥胖对不孕的经济影响:评估生育护理成本和结果的框架。
Hum Reprod Update. 2010 May-Jun;16(3):246-54. doi: 10.1093/humupd/dmp053. Epub 2010 Jan 7.
9
The relative contribution of IVF to the total ongoing pregnancy rate in a subfertile cohort.体外受精对生育能力低下队列中持续妊娠率的相对贡献。
Hum Reprod. 2010 Jan;25(1):118-26. doi: 10.1093/humrep/dep341. Epub 2009 Oct 24.
10
The direct health services costs of providing assisted reproduction services in overweight or obese women: a retrospective cross-sectional analysis.超重或肥胖女性提供辅助生殖服务的直接医疗服务成本:一项回顾性横断面分析。
Hum Reprod. 2009 Mar;24(3):633-9. doi: 10.1093/humrep/den424. Epub 2008 Dec 5.

基于肥胖而拒绝生育治疗是不合理的。

It is not justified to reject fertility treatment based on obesity.

作者信息

Koning Aafke, Mol Ben Willem, Dondorp Wybo

机构信息

Ziekenhuis Amstelland, Department of Obstetrics and gynecology, Laan van de Helende Meesters 8, Amstelveen, The Netherlands.

University of Adelaide, The Robinson Institute, School of Pediatrics and Reproductive Health, Adelaide, Australia.

出版信息

Hum Reprod Open. 2017 Jul 28;2017(2):hox009. doi: 10.1093/hropen/hox009. eCollection 2017.

DOI:10.1093/hropen/hox009
PMID:30895227
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6276680/
Abstract

Obesity can lead to anovulation and subfertility. Around the world fertility treatment is withheld from women above a certain BMI, with a threshold ranging from 25 to 40 kg/m. The proponents of this policy use three different arguments to justify their restrictions: risks for the woman, health and wellbeing of the future child, and importance for society. In this article we critically appraise these arguments. We conclude that obese women should be informed about the consequences of their weight on fertility and pregnancy complications and encouraged to lose weight. If, however, a woman is unable to lose weight despite effort, we feel there is no argument to withhold treatment from her. This would be unjustified with respect to the treatment of other women with a high risk of complications.

摘要

肥胖会导致无排卵和生育力低下。在世界各地,对于体重指数高于一定值的女性,生育治疗不予提供,该阈值范围为25至40千克/平方米。这项政策的支持者使用三种不同的论据来为他们的限制进行辩护:对女性的风险、未来孩子的健康和幸福以及对社会的重要性。在本文中,我们对这些论据进行批判性评估。我们得出结论,应该告知肥胖女性其体重对生育和妊娠并发症的影响,并鼓励她们减肥。然而,如果一名女性尽管努力但仍无法减肥,我们认为没有理由不给她提供治疗。这对于治疗其他有高并发症风险的女性来说是不合理的。