Department of Otolaryngology-Head and Neck Surgery, Universidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario "Dr. José Eleuterio González", Av. Madero y Gonzalitos Colonia Mitras Centro, CP 64460, Monterrey, NL, Mexico.
Department of Radiology and Imaging, Universidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario "Dr. José Eleuterio González", Monterrey, Mexico.
Eur Arch Otorhinolaryngol. 2019 Jun;276(6):1701-1705. doi: 10.1007/s00405-019-05390-z. Epub 2019 Mar 20.
To identify and determine variations on eye distance in patients with bilateral nasal polyposis (BNP) compared to a healthy control group.
This is a case-control study that included 20 BNP patients and 40 healthy controls. We included all patients with BNP confirmed by pathology and a computed tomography scan. A healthy control group was admitted, filtered by the exclusion criteria of nasal polyposis, craniofacial malformations, and encephalocele. Paranasal sinus CT scans were performed in all participants, and two measures were evaluated, the interoptic (soft tissue) and the interzygomatic (bone structure) distances.
A total of 20 BNP subjects, 13 (65%) male and 7 (35%) female, with a mean age of 38.8 years, and 40 healthy controls, 16 (40%) male and 24 (60%) female with a mean age of 43.2 years, were included. The mean interoptic distance was 69.7 mm (71.9 mm men, 66.4 mm women) and interzygomatic distance was 103.1 mm (104.5 mm men, 100.6 mm women). A significant increase of the interoptic (p < 0.001) and interzygomatic (p < 0.002) measurements was found in patients with polyposis compared to the controls. In the receptor operative curve analysis, the interoptic distance had an area under a curve of 96% and the threshold that maximizes the sensitivity and specificity was 59.85 mm (sensitivity 90%, specificity 95%, PPV 90%, NPV 95%).
An increase in ocular and orbital distances was identified in patients with BNP. Polyposis may be identified by measuring eye separation. The established cut point distance identifies patients that may benefit from follow-up. Further research in this study line is suggested.
与健康对照组相比，确定并比较双侧鼻息肉（BNP）患者的眼距变化。
这是一项病例对照研究，共纳入 20 例 BNP 患者和 40 例健康对照者。我们纳入了所有经病理和计算机断层扫描（CT）检查证实为 BNP 的患者。健康对照组经排除标准筛选，排除了鼻息肉、颅面畸形和脑膨出的患者。所有参与者均行鼻窦 CT 扫描，评估了两个指标，即视距（软组织）和面距（骨结构）。
共纳入 20 例 BNP 患者，男性 13 例（65%），女性 7 例（35%），平均年龄 38.8 岁；纳入 40 例健康对照者，男性 16 例（40%），女性 24 例（60%），平均年龄 43.2 岁。平均视距为 69.7mm（男性 71.9mm，女性 66.4mm），面距为 103.1mm（男性 104.5mm，女性 100.6mm）。与对照组相比，息肉患者的视距（p<0.001）和面距（p<0.002）均显著增加。在受体操作曲线分析中，视距的曲线下面积为 96%，最大灵敏度和特异性的阈值为 59.85mm（灵敏度 90%，特异性 95%，阳性预测值 90%，阴性预测值 95%）。
BNP 患者的眼距和眶距均增加。通过测量眼距可识别息肉。确定的截断距离可识别出可能需要随访的患者。建议对此研究领域进行进一步研究。
