Moré Margret I
analyze & realize GmbH, Berlin, Deutschland.
, Klaustaler Str. 7, 13187, Berlin, Deutschland.
MMW Fortschr Med. 2019 Mar;161(Suppl 4):20-24. doi: 10.1007/s15006-019-0290-5. Epub 2019 Mar 20.
Saccharomyces boulardii CNCM I-745 is a probiotic medicinal yeast used in the prevention and treatment of diarrhea. It has numerous effects, i. a. immunological and antitoxin effects, it binds pathogens and has a beneficial effect on the intestinal microbiota. In addition, pronounced trophic effects were detected.
The focus of this review is on the effects of S. boulardii CNCM I-745 on digestive enzymes located in the brush border membrane. An important role in this context is attributed to polyamines which are synthesized and secreted by S. boulardii CNCM I-745.
Polyamines are essential for cell proliferation and differentiation. They enhance the expression of intestinal enzymes as well as nutrient transport systems and directly influence the nucleic acid binding capacity. S. boulardii CNCM I-745 induces signals via mitogen-activated protein kinase cascades (MAP kinase pathway) and influences the PI3 kinase signaling pathway. Furthermore, S. boulardii CNCM I-745 secretes certain enzymes that promote nutrient delivery to both the yeast itself and the host organism. The increased presence of digestive enzymes obviously contributes significantly to the clinical effect of S. boulardii CNCM I-745.
布拉氏酵母菌CNCM I-745是一种用于预防和治疗腹泻的益生菌药用酵母。它具有多种作用，如免疫和抗毒素作用，能结合病原体并对肠道微生物群产生有益影响。此外，还检测到明显的营养作用。
本综述的重点是布拉氏酵母菌CNCM I-745对位于刷状缘膜上的消化酶的影响。在这方面，多胺起着重要作用，多胺由布拉氏酵母菌CNCM I-745合成并分泌。
多胺对细胞增殖和分化至关重要。它们可增强肠道酶以及营养物质转运系统的表达，并直接影响核酸结合能力。布拉氏酵母菌CNCM I-745通过丝裂原活化蛋白激酶级联反应（MAP激酶途径）诱导信号，并影响PI3激酶信号通路。此外，布拉氏酵母菌CNCM I-745分泌某些酶，促进营养物质向酵母自身和宿主生物体的传递。消化酶含量的增加显然对布拉氏酵母菌CNCM I-745的临床效果有显著贡献。
