包载鱼油蛋白标记金纳米粒子的脂质体用于骨关节炎的关节腔内治疗。
Liposome-encapsulated fish oil protein-tagged gold nanoparticles for intra-articular therapy in osteoarthritis.
机构信息
Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, Maharashtra, 400076, India.
Department of Pediatrics, Division of Hematology, The Children's Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA.
出版信息
Nanomedicine (Lond). 2019 Apr;14(7):871-887. doi: 10.2217/nnm-2018-0221. Epub 2019 Mar 21.
AIM
To provide multilayered combination therapies encompassing nanoparticles and organic peptides and to assess their efficacy in the treatment of arthritis.
MATERIALS & METHODS: Fish oil protein (FP) was isolated from fish oil glands and tagged with spherical gold nanoparticles (GNPs). Tagged GNPs were encapsulated in DPPC liposomes (FP-GNP-DPPC) and characterized.
RESULTS & CONCLUSION: FP increased the hydrophilicity of GNP, while encapsulation of FP-GNP within liposomes increased the hydrophobicity. In vitro release studies of FP-GNP-DPPC exhibited sustained release of FP in simulated synovial fluid. FP-GNP-DPPC injected into intra-articular joints of rats displayed anti-osteoarthritic effects in osteoarthritic rat model. This is the first study to report the anti-osteoarthritic activity of FP and DPPC encapsulated FP-GNP liposomes.
目的
提供包含纳米粒子和有机肽的多层次联合疗法，并评估其在关节炎治疗中的疗效。
材料与方法
从鱼油腺中分离出鱼油蛋白（FP），并将其标记为球形金纳米粒子（GNPs）。标记的 GNPs 被包裹在 DPPC 脂质体（FP-GNP-DPPC）中，并进行了表征。
结果与结论
FP 增加了 GNP 的亲水性，而将 FP-GNP 包裹在脂质体中则增加了疏水性。FP-GNP-DPPC 的体外释放研究显示，在模拟滑液中 FP 呈现持续释放。将 FP-GNP-DPPC 注入大鼠关节内，在骨关节炎大鼠模型中显示出抗骨关节炎作用。这是首次报道 FP 和 DPPC 包封 FP-GNP 脂质体的抗骨关节炎活性的研究。
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