Department of Molecular Biology and Genetics, Bogazici University, 34342 Istanbul, Türkiye.
Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford OX3 7LD, UK.
Molecules. 2023 Jul 27;28(15):5694. doi: 10.3390/molecules28155694.
Organic and inorganic nanoparticles (NPs) have attracted significant attention due to their unique physico-chemical properties, which have paved the way for their application in numerous fields including diagnostics and therapy. Recently, hybrid nanomaterials consisting of organic nanocompartments (e.g., liposomes, micelles, poly (lactic-co-glycolic acid) NPs, dendrimers, or chitosan NPs) encapsulating inorganic NPs (quantum dots, or NPs made of gold, silver, silica, or magnetic materials) have been researched for usage in vivo as drug-delivery or theranostic agents. These classes of hybrid multi-particulate systems can enable or facilitate the use of inorganic NPs in biomedical applications. Notably, integration of inorganic NPs within organic nanocompartments results in improved NP stability, enhanced bioavailability, and reduced systemic toxicity. Moreover, these hybrid nanomaterials allow synergistic interactions between organic and inorganic NPs, leading to further improvements in therapeutic efficacy. Furthermore, these platforms can also serve as multifunctional agents capable of advanced bioimaging and targeted delivery of therapeutic agents, with great potential for clinical applications. By considering these advancements in the field of nanomedicine, this review aims to provide an overview of recent developments in the use of hybrid nanoparticulate systems that consist of organic nanocompartments encapsulating inorganic NPs for applications in drug delivery, bioimaging, and theranostics.
有机纳米粒子和无机纳米粒子（NPs）由于其独特的物理化学性质而受到了广泛关注，这为它们在包括诊断和治疗在内的众多领域的应用铺平了道路。最近，由有机纳米容器（例如脂质体、胶束、聚（乳酸-共-乙醇酸） NPs、树枝状大分子或壳聚糖 NPs）包裹的无机 NPs（量子点或由金、银、二氧化硅或磁性材料制成的 NPs）组成的混合纳米材料已被研究用于体内作为药物输送或治疗诊断剂。这些类别的混合多颗粒系统可以使无机 NPs 在生物医学应用中得以使用或促进其使用。值得注意的是，将无机 NPs 整合到有机纳米容器内可提高 NP 的稳定性、增强生物利用度并降低系统毒性。此外，这些混合纳米材料允许有机和无机 NPs 之间的协同相互作用，从而进一步提高治疗效果。此外，这些平台还可以作为多功能试剂，能够进行高级生物成像和治疗剂的靶向传递，具有很大的临床应用潜力。通过考虑纳米医学领域的这些进展，本综述旨在概述最近在使用有机纳米容器封装无机 NPs 的混合纳米颗粒系统在药物输送、生物成像和治疗诊断中的应用方面的最新进展。
