铱催化芳基烯酰胺和烯基氨基甲酸酯的对映选择性烯丙基化反应。
Iridium-Catalyzed Enantioselective Allylation of Aryl Enamides and Enecarbamates.
作者信息
Yue Bei-Bei, Deng Yi, Zheng Yu, Wei Kun, Yang Yu-Rong
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany , Chinese Academy of Sciences , Kunming 650201 , China.
University of Chinese Academy of Sciences , Beijing 100049 , China.
出版信息
Org Lett. 2019 Apr 5;21(7):2449-2452. doi: 10.1021/acs.orglett.9b00764. Epub 2019 Mar 21.
Aromatic enamide and enecarbamate as a novel type of nucleophile in the asymmetric allylation of branched, racemic allylic alcohols to give homoallylic ketones has been described. Enabled by Carreira's chiral Ir (P, olefin) complex, the reactions proceed in good yields with excellent enantioselectivities.
已报道了芳香烯酰胺和烯基氨基甲酸酯作为一种新型亲核试剂，用于支链外消旋烯丙醇的不对称烯丙基化反应以生成高烯丙基酮。在卡雷拉手性铱（磷，烯烃）配合物的作用下，反应以良好的产率和优异的对映选择性进行。
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