• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

miRNA-153 通过 Nrf2/ARE 细胞保护作用对抗异氟醚诱导的神经毒性。

The function of miRNA‑153 against isoflurane‑induced neurotoxicity via Nrf2/ARE cytoprotection.

机构信息

Department of Anesthesiology, Changzhou No. 2 People's Hospital Affiliated to Nanjing Medical University, Changzhou, Jiangsu 213000, P.R. China.

出版信息

Mol Med Rep. 2019 May;19(5):4001-4010. doi: 10.3892/mmr.2019.10056. Epub 2019 Mar 19.

DOI:10.3892/mmr.2019.10056
PMID:30896808
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6471563/
Abstract

The present study aimed to investigate the function of micro (mi)RNA‑153 against isoflurane‑induced neurotoxicity and its mechanism. In isoflurane‑induced mice, miRNA‑153 expression was downregulated compared with in the control group. Downregulation of miRNA‑153 induced neurocyte apoptosis, reduced cell growth and promoted oxidative stress in an in vitro model. Overexpression of miRNA‑153 reduced oxidative stress, promoted cell growth and inhibited neurocyte apoptosis within an in vitro model. Downregulation of miRNA‑153 suppressed nuclear erythroid‑2 related factor 2 (Nrf2)/antioxidant response element (ARE) signaling pathway, which was induced via the overexpression of miRNA‑153 in vitro. The Nrf2 agonist, dimethyl fumarate (2.5 µM), induced the Nrf2/ARE signaling pathway and reduced oxidative stress to induce neurocyte apoptosis in vitro following treatment with anti‑miRNA‑153. The results of the present study suggested the function of miRNA‑153 against neurotoxicity via Nrf2/ARE‑mediated cytoprotection.

摘要

本研究旨在探讨 micro (mi)RNA-153 对异氟醚诱导的神经毒性的作用及其机制。与对照组相比，异氟醚诱导的小鼠中 miRNA-153 的表达下调。miRNA-153 下调诱导神经细胞凋亡，减少细胞生长，并促进体外模型中的氧化应激。miRNA-153 的过表达减少了氧化应激，促进了细胞生长，并抑制了体外模型中的神经细胞凋亡。miRNA-153 的下调抑制了核红细胞 2 相关因子 2 (Nrf2)/抗氧化反应元件 (ARE) 信号通路，该通路在体外通过 miRNA-153 的过表达诱导。Nrf2 激动剂丁二酸二甲酯 (2.5µM) 诱导 Nrf2/ARE 信号通路，并减少氧化应激，从而在使用抗 miRNA-153 处理后诱导体外神经细胞凋亡。本研究的结果表明，miRNA-153 通过 Nrf2/ARE 介导的细胞保护作用对抗神经毒性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93aa/6471563/cf220e31a1d5/MMR-19-05-4001-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93aa/6471563/a9cae19d205e/MMR-19-05-4001-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93aa/6471563/e4074224d47d/MMR-19-05-4001-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93aa/6471563/f78aa9ff6c69/MMR-19-05-4001-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93aa/6471563/0034d7bce113/MMR-19-05-4001-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93aa/6471563/6f53853e9ae4/MMR-19-05-4001-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93aa/6471563/7a994d00e4f4/MMR-19-05-4001-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93aa/6471563/c369b9dc5c14/MMR-19-05-4001-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93aa/6471563/cf220e31a1d5/MMR-19-05-4001-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93aa/6471563/a9cae19d205e/MMR-19-05-4001-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93aa/6471563/e4074224d47d/MMR-19-05-4001-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93aa/6471563/f78aa9ff6c69/MMR-19-05-4001-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93aa/6471563/0034d7bce113/MMR-19-05-4001-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93aa/6471563/6f53853e9ae4/MMR-19-05-4001-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93aa/6471563/7a994d00e4f4/MMR-19-05-4001-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93aa/6471563/c369b9dc5c14/MMR-19-05-4001-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93aa/6471563/cf220e31a1d5/MMR-19-05-4001-g07.jpg

相似文献

1
The function of miRNA‑153 against isoflurane‑induced neurotoxicity via Nrf2/ARE cytoprotection.miRNA-153 通过 Nrf2/ARE 细胞保护作用对抗异氟醚诱导的神经毒性。
Mol Med Rep. 2019 May;19(5):4001-4010. doi: 10.3892/mmr.2019.10056. Epub 2019 Mar 19.
2
Downregulation of microRNA-302b-3p relieves oxygen-glucose deprivation/re-oxygenation induced injury in murine hippocampal neurons through up-regulating Nrf2 signaling by targeting fibroblast growth factor 15/19.下调 microRNA-302b-3p 通过靶向成纤维细胞生长因子 15/19 上调 Nrf2 信号通路缓解氧糖剥夺/复氧诱导的小鼠海马神经元损伤。
Chem Biol Interact. 2019 Aug 25;309:108705. doi: 10.1016/j.cbi.2019.06.018. Epub 2019 Jun 11.
3
MicroRNA-98-5p ameliorates oxygen-glucose deprivation/reoxygenation (OGD/R)-induced neuronal injury by inhibiting Bach1 and promoting Nrf2/ARE signaling.微小 RNA-98-5p 通过抑制 Bach1 并促进 Nrf2/ARE 信号通路来改善氧葡萄糖剥夺/复氧（OGD/R）诱导的神经元损伤。
Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):114-121. doi: 10.1016/j.bbrc.2018.10.182. Epub 2018 Nov 16.
4
Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson's disease by enhancing Nrf2 activity.富马酸二甲酯通过增强Nrf2活性减轻6-羟基多巴胺诱导的SH-SY5Y细胞和帕金森病动物模型中的神经毒性。
Neuroscience. 2015 Feb 12;286:131-40. doi: 10.1016/j.neuroscience.2014.11.047. Epub 2014 Nov 29.
5
Naringenin protects against 6-OHDA-induced neurotoxicity via activation of the Nrf2/ARE signaling pathway.柚皮素通过激活Nrf2/ARE信号通路来抵御6-羟基多巴胺诱导的神经毒性。
Neuropharmacology. 2014 Apr;79:380-8. doi: 10.1016/j.neuropharm.2013.11.026. Epub 2013 Dec 11.
6
SIRT6 protects retinal ganglion cells against hydrogen peroxide-induced apoptosis and oxidative stress by promoting Nrf2/ARE signaling via inhibition of Bach1.SIRT6 通过抑制 Bach1 促进 Nrf2/ARE 信号通路来保护视网膜神经节细胞免受过氧化氢诱导的细胞凋亡和氧化应激。
Chem Biol Interact. 2019 Feb 25;300:151-158. doi: 10.1016/j.cbi.2019.01.018. Epub 2019 Jan 17.
7
Naringenin reduces oxidative stress and improves mitochondrial dysfunction via activation of the Nrf2/ARE signaling pathway in neurons.柚皮苷通过激活神经元中的 Nrf2/ARE 信号通路来减少氧化应激并改善线粒体功能障碍。
Int J Mol Med. 2017 Nov;40(5):1582-1590. doi: 10.3892/ijmm.2017.3134. Epub 2017 Sep 13.
8
Asiatic acid enhances Nrf2 signaling to protect HepG2 cells from oxidative damage through Akt and ERK activation.齐墩果酸通过激活Akt和ERK增强Nrf2信号通路，保护HepG2细胞免受氧化损伤。
Biomed Pharmacother. 2017 Apr;88:252-259. doi: 10.1016/j.biopha.2017.01.067. Epub 2017 Jan 19.
9
MiR-455-3p activates Nrf2/ARE signaling via HDAC2 and protects osteoblasts from oxidative stress.miR-455-3p 通过 HDAC2 激活 Nrf2/ARE 信号通路，保护成骨细胞免受氧化应激。
Int J Biol Macromol. 2018 Feb;107(Pt B):2094-2101. doi: 10.1016/j.ijbiomac.2017.10.080. Epub 2017 Oct 16.
10
Lipoamide Ameliorates Oxidative Stress via Induction of Nrf2/ARE Signaling Pathway in PC12 Cells.硫辛酸通过诱导 PC12 细胞 Nrf2/ARE 信号通路减轻氧化应激。
J Agric Food Chem. 2019 Jul 24;67(29):8227-8234. doi: 10.1021/acs.jafc.9b02680. Epub 2019 Jul 12.

引用本文的文献

1
Baicalin Exhibits a Protective Effect against Cisplatin-Induced Cytotoxic Damage in Canine Renal Tubular Epithelial Cells.黄芩苷对顺铂诱导的犬肾小管上皮细胞毒性损伤具有保护作用。
Metabolites. 2023 Nov 24;13(12):1173. doi: 10.3390/metabo13121173.
2
MicroRNAs-Based Theranostics against Anesthetic-Induced Neurotoxicity.基于微小RNA的麻醉诱导神经毒性诊疗方法
Pharmaceutics. 2023 Jun 27;15(7):1833. doi: 10.3390/pharmaceutics15071833.
3
Recent progress on the role of non-coding RNA in postoperative cognitive dysfunction.非编码RNA在术后认知功能障碍中作用的最新进展

本文引用的文献

1
SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model.白藜芦醇通过激活 SIRT1 减少实验性大鼠蛛网膜下腔出血模型中的脑水肿和神经元凋亡。
Mol Med Rep. 2017 Dec;16(6):9627-9635. doi: 10.3892/mmr.2017.7773. Epub 2017 Oct 12.
2
Glutaredoxin 1 (GRX1) inhibits oxidative stress and apoptosis of chondrocytes by regulating CREB/HO-1 in osteoarthritis.谷氧还蛋白1（GRX1）通过调节骨关节炎中CREB/HO-1抑制软骨细胞的氧化应激和凋亡。
Mol Immunol. 2017 Oct;90:211-218. doi: 10.1016/j.molimm.2017.08.006. Epub 2017 Aug 23.
3
NOX4- and Nrf2-mediated oxidative stress induced by silver nanoparticles in vascular endothelial cells.
Front Cell Neurosci. 2022 Oct 13;16:1024475. doi: 10.3389/fncel.2022.1024475. eCollection 2022.
4
Protective effects of chlorogenic acid on isoflurane-induced cognitive impairment of aged mice.绿原酸对异氟烷所致老年小鼠认知功能障碍的保护作用。
Food Sci Nutr. 2022 Jun 20;10(10):3492-3500. doi: 10.1002/fsn3.2952. eCollection 2022 Oct.
5
Comprehensive overview of Nrf2-related epigenetic regulations involved in ischemia-reperfusion injury.Nrf2 相关的表观遗传调控在缺血再灌注损伤中的综合概述。
Theranostics. 2022 Sep 11;12(15):6626-6645. doi: 10.7150/thno.77243. eCollection 2022.
6
MicroRNA-424-5p Alleviates Isoflurane Anesthesia-Induced Neurotoxicity in Human Embryonic Stem Cell-Derived Neurons by Targeting FASN.miR-424-5p 通过靶向 FASN 减轻异氟烷麻醉诱导的人胚胎干细胞源性神经元神经毒性
Comput Math Methods Med. 2022 Jul 13;2022:2517463. doi: 10.1155/2022/2517463. eCollection 2022.
7
Ginsenoside Rb1 Attenuates Triptolide-Induced Cytotoxicity in HL-7702 Cells the Activation of Keap1/Nrf2/ARE Pathway.人参皂苷Rb1减轻雷公藤甲素诱导的HL-7702细胞毒性及Keap1/Nrf2/ARE通路的激活。
Front Pharmacol. 2022 Jan 3;12:723784. doi: 10.3389/fphar.2021.723784. eCollection 2021.
8
Inhibition of miR-448-3p Attenuates Cerebral Ischemic Injury by Upregulating Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2).抑制miR-448-3p通过上调核因子红细胞2相关因子2（Nrf2）减轻脑缺血损伤。
Neuropsychiatr Dis Treat. 2021 Oct 19;17:3147-3158. doi: 10.2147/NDT.S310495. eCollection 2021.
9
Longitudinal impact on rat cardiac tissue transcriptomic profiles due to acute intratracheal inhalation exposures to isoflurane.急性经气管吸入异氟醚对大鼠心脏组织转录组谱的纵向影响。
PLoS One. 2021 Oct 14;16(10):e0257241. doi: 10.1371/journal.pone.0257241. eCollection 2021.
10
MicroRNA-183-5p protects human derived cell line SH-SY5Y cells from mepivacaine-induced injury.微小 RNA-183-5p 可保护人源性细胞系 SH-SY5Y 细胞免受甲哌卡因诱导的损伤。
Bioengineered. 2021 Dec;12(1):3177-3187. doi: 10.1080/21655979.2021.1946358.
银纳米颗粒诱导血管内皮细胞中 NOX4 和 Nrf2 介导的氧化应激。
J Appl Toxicol. 2017 Dec;37(12):1428-1437. doi: 10.1002/jat.3511. Epub 2017 Aug 16.
4
Differentiation impairs Bach1 dependent HO-1 activation and increases sensitivity to oxidative stress in SH-SY5Y neuroblastoma cells.分化会损害 Bach1 依赖性 HO-1 激活，并增加 SH-SY5Y 神经母细胞瘤细胞对氧化应激的敏感性。
Sci Rep. 2017 Aug 8;7(1):7568. doi: 10.1038/s41598-017-08095-7.
5
Roles of the Nrf2/HO-1 pathway in the anti-oxidative stress response to ischemia-reperfusion brain injury in rats.Nrf2/HO-1通路在大鼠脑缺血再灌注损伤抗氧化应激反应中的作用
Eur Rev Med Pharmacol Sci. 2017 Apr;21(7):1532-1540.
6
Hydrogen-rich saline attenuates isoflurane-induced caspase-3 activation and cognitive impairment via inhibition of isoflurane-induced oxidative stress, mitochondrial dysfunction, and reduction in ATP levels.富氢盐水通过抑制异氟烷诱导的氧化应激、线粒体功能障碍以及ATP水平降低，减轻异氟烷诱导的半胱天冬酶-3激活和认知障碍。
Am J Transl Res. 2017 Mar 15;9(3):1162-1172. eCollection 2017.
7
Inhibition of microRNA-153 protects neurons against ischemia/reperfusion injury in an oxygen-glucose deprivation and reoxygenation cellular model by regulating Nrf2/HO-1 signaling.在氧糖剥夺和复氧细胞模型中，抑制微小RNA-153通过调节Nrf2/HO-1信号通路保护神经元免受缺血/再灌注损伤。
J Biochem Mol Toxicol. 2017 Jul;31(7). doi: 10.1002/jbt.21905. Epub 2017 Feb 28.
8
Neuroprotective effects of vitexin against isoflurane-induced neurotoxicity by targeting the TRPV1 and NR2B signaling pathways.牡荆素通过靶向瞬时受体电位香草酸亚型1（TRPV1）和N-甲基-D-天冬氨酸受体2B（NR2B）信号通路对异氟烷诱导的神经毒性的神经保护作用。
Mol Med Rep. 2016 Dec;14(6):5607-5613. doi: 10.3892/mmr.2016.5948. Epub 2016 Nov 16.
9
Nobiletin ameliorates isoflurane-induced cognitive impairment via antioxidant, anti-inflammatory and anti-apoptotic effects in aging rats.诺米林通过抗氧化、抗炎和抗凋亡作用改善老龄大鼠异氟烷诱导的认知障碍。
Mol Med Rep. 2016 Dec;14(6):5408-5414. doi: 10.3892/mmr.2016.5919. Epub 2016 Nov 1.
10
NRF2 promotes breast cancer cell proliferation and metastasis by increasing RhoA/ROCK pathway signal transduction.核因子E2相关因子2（NRF2）通过增强RhoA/ROCK信号通路转导促进乳腺癌细胞的增殖和转移。
Oncotarget. 2016 Nov 8;7(45):73593-73606. doi: 10.18632/oncotarget.12435.