College of Engineering, Swansea University, Fabian Way, Crymlyn Burrows, Bay Campus, Swansea, SA1 8EN, UK.
Institut des Biomolécules Max Mousseron, UMR 5247, Université de Montpellier, Faculté de Pharmacie, 34093, Montpellier, France.
Chembiochem. 2019 Sep 2;20(17):2198-2202. doi: 10.1002/cbic.201900112. Epub 2019 Jun 24.
Theranostics involves finding the biomarkers of a disease, fighting them through site specific drug delivery and following them for prognosis of the disease. Microneedle array technology has been used for drug delivery and extended for continuous monitoring of analytes present in the skin compartment. We envisage the use of microneedle arrays for future theranostic applications. The potential of combining microneedle array-based drug delivery and diagnostics as part of closed-loop control system for the management of diseases and delivery of precision drugs in individual patients is reported in this paper.
治疗涉及寻找疾病的生物标志物，通过靶向药物传递来对抗它们，并跟踪它们以预测疾病的预后。微针阵列技术已被用于药物传递，并扩展用于持续监测皮肤隔室中存在的分析物。我们设想将微针阵列用于未来的治疗应用。本文报道了将基于微针阵列的药物传递和诊断相结合作为疾病管理闭环控制系统的一部分，以及为个体患者提供精准药物的潜力。
