固态化学与药物化学的结合作为治疗平台合成的基础。
The Combination of Solid-State Chemistry and Medicinal Chemistry as the Basis for the Synthesis of Theranostics Platforms.
机构信息
Almazov National Medical Research Centre, Institute of Experimental Medicine, 2 Akkuratova Str., 197341 Saint Petersburg, Russia.
Institute of Chemistry, Saint Petersburg State University, 7/9 Universitetskaya Emb., 199034 Saint Petersburg, Russia.
出版信息
Biomolecules. 2021 Oct 19;11(10):1544. doi: 10.3390/biom11101544.
This review presents the main patterns of synthesis for theranostics platforms. We examine various approaches to the interpretation of theranostics, statistics of publications drawn from the PubMed database, and the solid-state and medicinal chemistry methods used for the formation of nanotheranostic objects. We highlight and analyze chemical methods for the modification of nanoparticles, synthesis of spacers with functional end-groups, and the immobilization of medicinal substances and fluorophores. An overview of the modern solutions applied in various fields of medicine is provided, along with an outline of specific examples and an analysis of modern trends and development areas of theranostics as a part of personalized medicine.
这篇综述介绍了治疗诊断平台的主要合成模式。我们考察了治疗诊断学的各种解释方法、从 PubMed 数据库中提取的出版物的统计学数据，以及用于形成纳米治疗诊断物体的固态和药物化学方法。我们突出并分析了用于修饰纳米粒子、合成带有功能端基的间隔物，以及固定药物物质和荧光团的化学方法。提供了在医学各个领域应用的现代解决方案概述，以及具体示例的概要和对治疗诊断学作为个性化医学一部分的现代趋势和发展领域的分析。
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