Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan.
National Yang-Ming University School of Medicine, Taipei, Taiwan.
J Biomed Mater Res B Appl Biomater. 2020 Jan;108(1):8-13. doi: 10.1002/jbm.b.34359. Epub 2019 Mar 21.
In the field of ophthalmology, postoperative endophthalmitis (POE) is a serious surgical complication, which may lead to poor visual outcome even after the infection has been controlled. In the study, we develop a sustained drug releasing system loaded with levofloxacin which is expected to be effective against common pathogens responsible for POE for at least 7 days after single application at the end of surgery. The results of study showed that the sol-gel transition temperature of the levofloxacin-loaded chitosan-gelatin-based solution was ~34°C. The gelation time of the developed formulation was ~81 s at 34°C. The results showed that the osmolality of developed hydrogel was 304 mOsm/L. The in vitro drug release studies revealed that levofloxacin release from the developed hydrogel displayed a sustained-release profile. The long-term antibacterial property of the developed hydrogel has been demonstrated. The biocompatibility of the developed hydrogel was evaluated in vitro. These results suggest that the levofloxacin-containing hydrogel could be applied to ocular surface at the end of ophthalmic surgery, without the risks of intracameral injection of antibiotics. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 108B:8-13, 2020.
在眼科学领域，术后眼内炎（POE）是一种严重的手术并发症，即使感染得到控制，也可能导致视力不佳。在这项研究中，我们开发了一种载有左氧氟沙星的持续药物释放系统，预计在手术后单次应用结束时，至少在 7 天内对 POE 常见病原体有效。研究结果表明，载左氧氟沙星的壳聚糖-明胶基溶液的溶胶-凝胶转变温度约为 34°C。所开发制剂在 34°C 时的胶凝时间约为 81s。结果表明，所开发水凝胶的渗透压为 304mOsm/L。体外药物释放研究表明，开发的水凝胶中左氧氟沙星的释放呈现出持续释放的特点。已证明开发的水凝胶具有长期的抗菌性能。已在体外评估了开发的水凝胶的生物相容性。这些结果表明，载左氧氟沙星的水凝胶可以在眼科手术后应用于眼表面，而不会有眼内注射抗生素的风险。 © 2019 威利父子出版公司
