Material Science and Engineering College, Qingdao University, Qingdao, Shandong, 266071, People's Republic of China.
Institute of Complexity Science, Automation College, Qingdao University, Qingdao, Shandong, 266071, People's Republic of China.
J Biomed Mater Res A. 2019 Sep;107(9):1909-1916. doi: 10.1002/jbm.a.36677. Epub 2019 Apr 9.
A novel voriconazole (VCZ)-loaded injectable hydrogel was in situ synthetized via a Schiff base reaction between polyaldehyde dextran (PAD) and carboxymethyl chitosan (CMCTS) for intraocular drug loading and release. Water-insoluble VCZ, which is an effective agent in clinic treating fungal endophthalmitis, was loaded through the inclusion into the β-cyclodextrin (β-CD) cavity based on host-guest interaction on the linear poly β-CD chain, which was in situ twined in the cross-linked hydrogel structure. The gelation time, degradation, and drug release process were investigated by studying three kinds of hydrogels with different volume ratio of PAD to CMCTS resolving in phosphate buffered saline (PBS) solution (3:7, 6:7, 9:7), respectively. The property of VCZ-loaded injectable hydrogel should be adjusted through changing the cross-linked density of the hydrogel, the molecular weight or concentration of the linear poly β-CD to meet the treating requirement, and a multistage drug controlled-release mechanism was proposed. In conclusion, the VCZ-loaded in situ injectable hydrogel should be offered as a promising strategy for intraocular drug delivery in vitreous cavity for the treatment of fungal endophthalmitis. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1909-1916, 2019.
一种新型伏立康唑（VCZ）载体制剂原位合成通过席夫碱反应聚醛葡聚糖（PAD）和羧甲基壳聚糖（CMCTS）用于眼内药物加载和释放。水不溶性 VCZ，是一种有效的治疗真菌性眼内炎的药物，是通过包含到β-环糊精（β-CD）空腔内基于主客体相互作用的线性聚β-CD 链，这是原位交织在交联水凝胶结构。通过研究三种不同体积比的 PAD 与 CMCTS 在磷酸盐缓冲盐水（PBS）溶液（3：7、6：7、9：7）中的凝胶时间、降解和药物释放过程，分别解决。载 VCZ 可注射水凝胶的性能应通过改变水凝胶的交联密度、线性聚β-CD 的分子量或浓度来调整，以满足治疗要求，并提出了一种多阶段药物控释机制。总之，载 VCZ 的原位可注射水凝胶可为治疗真菌性眼内炎的玻璃体内眼内药物输送提供一种有前途的策略。© 2019 年威利父子公司。J 生物医学材料研究部分 A：107A：1909-1916，2019。
